[The detection of nifedipine in biological materials].

The objective of the present study was to find optimal conditions for the isolation of nifedipine from biological materials by ethylacetate. It was shown that nifedipine can be purified from co-extracted substances of the biological material on a Silasorb C-18 column with the size of the particles 30 microns. The authors propose to use thin-layer chromatography, IR spectrophotometry, and reverse-phase high performance liquid chromatography for the identification and quantitative determination of nifedipine extracted from cadaveric liver samples.

[Study of eugenol distribution in the body of warm-blooded animals after lethal poisoning].

This study was designed to investigate the distribution of eugenol (2-methoxy-4-allylhydroxybenzene) in different tissues of homoiothermal animals (rats) after the intragastric administration of this toxic agents. It was shown that 2-methoxy-4-allylhydroxybenzene was present in large quantities in blood and splanchnic organs of the poisoned animals. The largest amounts of eugenol were found in the stomach and small intestine, their contents, spleen, and heart.

[Distribution of dipyridamole in the organism of warm-blooded animals].

Characteristics of distribution of dipyridamolum in the organism of warm-blooded animals (rats) after its intragastric introduction were studied. It was established that intact dipyridamolum in great quantity was present in visceras, blood and excrements of poisoned animals. In the greatest quantity dipyridamolum was present in excrements, tissues of stomach, small intestine, lung, spleen and kidney.

[Characteristics of dipyridamol isolation from biological material].

Acetone is proposed as an isolating agent for extraction of dipyridamolum from biological material. Optimal conditions of isolating dipyridamolum from human cadaveric liver tissue with acetone are determined and quantitative estimation of isolation results is provided.

[Extraction of 2-methyl-hydroxybenzene and 3-methyl-hydroxybenzene from water solutions].

The results related with extracting 2- and 3-methyloxibenzole from water solutions by 5 hydrophobic and 2 hydrophilic organic solvents are described in the paper. A variety of factors are shown to exert influence on an extraction degree: extraction agent (EA) nature, water-phase medium pH, EA saturation with water and adding of electrolytes to the water phase. A repetition factor needed to extract the preset quantities of studied compounds is estimated.