[Problem of clinico-roentgenological diagnosis of acute pneumonia in infants in their first few months of life].

Studies into the problems of diagnosing pneumonia in children of the first months of life carried out for many years have shown that pneumonia may be referred to the diseases with indefinite diagnostic criteria. In view of this fact the x-raying of the chest should be regarded as a method of varifying the diagnosis of pneumonia. The roentgenographic findings should be estimated bearing in mind the presence or lack of a syndrome such as bronchial obstruction and the epidemiological anamnesis data.

[Study of the changes in carbohydrate metabolism as a diagnostic test of acute hypothalamic syndrome in severe cranio-cerebral trauma].

A total of 66 patients who suffered a severe isolated or concomitant craniocerebral injury were examined. Additionally, a study was made of some indicators of carbohydrate metabolism in the general circulatory bed, acid-base state of the arterialized blood, partial oxygen tension and hemoglobin saturation with arterial blood oxygen. In 10 patients, the same indicators were compared to EEG alterations and the pulse constituent of the finger photoplethysmogram.

[Role of disorders of pentosephosphate pathway of glucose oxidation in the pathogenesis of the arrest of fetal development in miscarriage].

Activity of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase, the enzymes participating in the pentose phosphate pathway of glucose oxidation was studied in the blood of 15 normal fetuses and 25 abortuses as well as in 80 females (20 with normally advancing pregnancy, 40 with the signs of discontinuation and 20 patients with spontaneous abortion developed during 24-26 weeks of gestation). The impact of abnormal pentose phosphate pathway of glucose oxidation on the pathogenesis of fetal development arrest in females with incompetent pregnancy was established.

[Evaluation of airway resistance determined by whole-body plethysmography].

Methods of estimation of the airway resistance by flow-pressure curve obtained in whole-body plethysmography are investigated. The analysis of the physical processes controlling the flow-limitation during expiration shows that these methods are useful only for healthy subjects for the estimation of the airway resistance. The way for estimation of the airway resistance by flow-pressure curve is proposed.

[Role of the rise of pressure in the pulmonary artery in the distribution of perfusion and gas exchange in bronchial obstruction].

The experiments on the dogs revealed that the damage of lobar bronchus conduction resulted in the decrease of O2 tension in pulmonary venous blood of this lobe. The decrease in the ventilation and blood flow was found in the zone of obstruction by using tracers 133Xe and 99mTc. The pressure rise in the pulmonary artery caused by the spread of bronchial obstruction is one of the factors promoting the redistribution of perfusion into the reserve zones of lungs.

[Characteristics of the development during the 1st year of life of children born to mothers with threatened premature labor of the endocrine etiology].

As many as 50 children with the antenatal period complicated by prematurity risk were subjected to clinical and hormonal studies during the first year of life. To estimate adrenal function, excretion of 17-ketosteroids, corticoids and their fractions with urine was investigated. The children born in a satisfactory state with a physiological body weight and length demonstrated the lag in the establishment of motor and static functions as well as mental retardation.

[Comparative effectiveness of the sanatorium treatment of patients with bronchopulmonary diseases in the Leningrad health resort zone and at the climatotherapy sanatoria of Yalta and Kislovodsk].

Upon the comparison for Leningrad citizens, CNPD sanatorium treatment in climatic conditions of Leningrad Region was inferior in noway to that in southern climates of Yalta and Kislovodsk resorts as regards to relevant therapeutic response.

[The mechanism of the antihypoxic action of indomethacin, voltaren and ibuprofen].

The antihypoxic effects of indomethacin, voltaren and ibuprofen were studied experimentally by the parameters of acid-base equilibrium of the blood and the ratio of lactic and pyruvic acids in the blood during chronic hemic and respiratory hypoxia. The results of the studies suggested that indomethacin, voltaren and to a lesser extent ibuprofen in the tested doses (10% LD50) exerted the antihypoxic action that consisted in the improvement of oxygen supply to tissues under conditions of its deficiency, the decrease of incompletely oxidized products of metabolism, the enhancement of hemoglobin synthesis and the ability of voltaren to influence the increase of the number of erythrocytes in the peripheral blood.