Endocytoscopic microvasculature evaluation is a reliable new diagnostic method for colorectal lesions (with video).

Background: We previously reported on the efficacy of endocytoscopic classification (EC-C). However, the correlation of the endocytoscopic vascular (EC-V) pattern with diagnoses was unclear.

Objective: To assess the diagnostic accuracy of the EC-V pattern for colorectal lesions.

Diagnostic performance of endocytoscopy for evaluating the invasion depth of different morphological types of colorectal tumors.

Background And Aim: Endocytoscopy (EC) is a next-generation endoscopic technique that enables diagnostic imaging at 450× magnification. In the present study, we retrospectively evaluated the diagnostic performance of EC and magnifying chromoendoscopy (MCE) for diagnosing the invasion depth of colorectal tumors.

Methods: We investigated 330 lesions with a ≥10-mm tumor diameter that could be diagnosed by both MCE and EC.

Novel computer-aided diagnostic system for colorectal lesions by using endocytoscopy (with videos).

Background: Endocytoscopy enables in vivo observation of nuclei at 450× magnification during GI endoscopy, thus allowing precise prediction of lesion pathology. However, because it requires training and experience, it may be beneficial only when performed by expert endoscopists.

Objective: To develop and evaluate a novel computer-aided diagnosis system for endocytoscopic imaging (EC-CAD) of colorectal lesions.

Efficiency of endocytoscopy in differentiating types of serrated polyps.

Background: Accurate endoscopic criteria are needed to differentiate serrated polyps, including hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P), and traditional serrated adenoma (TSA), because some are precursors of colorectal cancers.

Objective: To determine the endocytoscopic features of each type of serrated polyp, especially the shapes of lumens and nuclei.

Design: Retrospective study.

Double staining with crystal violet and methylene blue is appropriate for colonic endocytoscopy: an in vivo prospective pilot study.

Background And Aim: Endocytoscopy (EC) at ultra-high magnification enables in vivo visualization of cellular atypia of gastrointestinal mucosae. Clear images are essential for precise diagnosis by EC. The aim of the present study was to evaluate the optimal staining method for EC in the colon.

Endocytoscopy can provide additional diagnostic ability to magnifying chromoendoscopy for colorectal neoplasms.

Background And Aim: Pit pattern (PIT) diagnosis with magnifying chromoendoscopy is effective diagnostic method for predicting a massively invasive submucosal colorectal cancer (SMm) which has possibility of metastasis, whereas endocytoscopy (EC) is recently reported to provide excellent diagnostic ability by enabling in vivo cellular visualization. The aim was to assess the additional diagnostic value of EC to PIT for diagnosing colorectal lesions.

Methods: We conducted a retrospective comparative analysis using a prospectively recorded database in a referral hospital.

Comprehensive diagnostic ability of endocytoscopy compared with biopsy for colorectal neoplasms: a prospective randomized noninferiority trial.

Background And Study Aims: Endocytoscopy enables observation at 450-fold magnification during gastrointestinal endoscopy, allowing on-site "optical biopsy." We compared the accuracies of endocytoscopy and standard biopsy for the diagnosis of colorectal neoplasms.

Patients And Methods: We performed a randomized, controlled, open-label trial of patients with colorectal lesions (≥ 5 mm) detected during colonoscopy in a tertiary referral center.