State-specific boundary conditions for nonequilibrium gas flows in slip regime.

Boundary conditions for fluid-dynamic variables of strongly nonequilibrium multicomponent gas mixture flows in slip regime are derived systematically by two different approaches. The flow is described in the framework of the state-to-state model for coupled detailed vibrational and chemical kinetics. The specular-diffusive model is applied for particles interaction with the solid wall, and the surface is assumed to be partially catalytic with possible state-specific chemical reactions and vibrational energy transitions described by a simple model based on the analogy with recombination coefficients.

Notch signaling defects in NK cells in patients with cancer.

Altered expressions of proto-oncogenes have been reported during normal lymphocytes mitogenesis and in T and B lymphocytes in patients with autoimmune diseases. We have recently demonstrated a significantly decreased expression of c-kit and c-Myc in NK cells isolated from patients with cancer, which might be related to the functional deficiency of NK cells in the tumor environment. Here, focusing on the regulatory mechanisms of this new clinical phenomenon, we determined expression of c-Myc, Notch1, Notch2, p-53, Cdk6, Rb and phosphorylated Rb in NK cells isolated from the healthy donors and cancer patients.

State-Resolved Dissociation and Exchange Reactions in CO Flows.

State-resolved chemical reactions in CO are studied by taking into account excitation of all vibrational modes and preferential reaction mechanisms. The effect of several parameters on the reaction rate coefficients is discussed; it is shown that the nonequilibrium factor in the expression for the rate coefficients of exchange reactions is much less sensitive to the number of accounted vibrational states and model parameters than that of dissociation. On the other hand, the choice of thermal equilibrium Arrhenius law parameters is crucial for the correct prediction of rate coefficients for both reactions.

Abnormal Expression of c-Myc Oncogene in NK Cells in Patients with Cancer.

Natural killer (NK) cells have received a lot of attention in recent years for the roles they play in immunity and particularly in antitumor immune responses. Although defects in NK cell functions are recognized as important mechanisms for immune evasion of malignant cells, molecular pathways regulating NK cell dysfunction and exhaustion in cancer are largely unknown. Here we tested whether the c-myc proto-oncogene, known to promote cell proliferation, growth, differentiation, and apoptosis by regulating the expression of numerous target genes, may be involved in the mechanism of NK cell abnormalities in patients with lung and gastric cancer.

Effect of Asymmetric Mode on CO State-to-State Vibrational-Chemical Kinetics.

Coupled state-to-state vibrational-chemical kinetics, gas dynamics, and heat transfer in the five-component mixture of dissociated CO are studied using the complete three-mode kinetic model and the reduced scheme involving mainly the vibrational states of the asymmetric mode. The emphasis is on the effect of asymmetric vibrations on the rate of dissociation, fluid dynamic variables, and heat flux. It is shown that intermode vibrational energy transitions between CO and CO asymmetric mode may considerably decrease the rate of dissociation; the presence of CO in the mixture quickly depletes high vibrational states and thus inhibits dissociation at low temperatures.

Functional heterogeneity of circulating T regulatory cell subsets in breast cancer patients.

Background: Regulatory T cells (Tregs) play a major role in tumor escape from immunosurveillance by suppressing effector cells. The number of Tregs is increased in tumor sites and peripheral blood of breast cancer patients. However, the data regarding phenotypic and functional heterogeneity of Treg subpopulations in breast cancer are limited.

Mechanisms of Coupled Vibrational Relaxation and Dissociation in Carbon Dioxide.

A complete vibrational state-specific kinetic scheme describing dissociating carbon dioxide mixtures is proposed. CO symmetric, bending and asymmetric vibrations and dissociation-recombination are strongly coupled through intermode vibrational energy transfers. Comparative study of state-resolved rate coefficients is carried out; the effect of different transitions may vary considerably with temperature.

Alterations of oncogenes expression in NK cells in patients with cancer.

Introduction: C-kit/SCF signaling plays a key role in regulating NK cell homeostasis, maturation, proliferation, and cytotoxicity. C-kit-deficiency in NK cells results in significant reduction of their number, suggesting an imperative role for c-kit signaling in NK cell biology. We have recently showed that human NK cells express not only c-kit-receptor, but also both membrane-bound and soluble forms of c-kit ligand-Stem cell factor.

Mutual effect of vibrational relaxation and chemical reactions in viscous multitemperature flows.

We study coupling of vibrational relaxation and chemical reactions in nonequilibrium viscous multitemperature flows. A general theoretical model is proposed on the basis of the Chapman-Enskog method modified for strongly nonequilibrium reacting flows; the model differs from models commonly used in computational fluid dynamics since it is able to capture additional cross-coupling terms arising in viscous flow due to compressibility and mutual influence of all nonequilibrium processes occurring in a mixture. The set of fluid dynamic equations is derived starting from the Boltzmann equation; the relaxation terms in these equations are described using the kinetic transport theory formalism.

Eucken correction in high-temperature gases with electronic excitation.

In the present paper, thermal conductivity coefficient of high-temperature molecular and atomic gases with excited electronic states is studied using both the kinetic theory algorithm developed by authors earlier and the well known simple expression for the thermal conductivity coefficient proposed by Eucken and generalized by Hirschfelder. The influence of large collision diameters of excited states on the thermal conductivity is discussed. The limit of validity of the Eucken correction is evaluated on the basis of the kinetic theory calculations; an improved model suitable for air species under high-temperature conditions is proposed.

Effects of L-selectin stimulation of the expression of chemokine receptor CXCR4 on NK cells of healthy donors and tumor patients.

We studied the effects of fucoidan (L-selectin ligand) on the expression and SDF-1-induced internalization of CXCR4 receptor on human NK cells of healthy donors and tumor patients. Fucoidan stimulated the expression of surface CXCR4 due to mobilization of the intracellular pool. The effect of fucoidan on CXCR4 expression in cancer patients was low.

Transport coefficients in nonequilibrium gas-mixture flows with electronic excitation.

In the present paper, a one-temperature model of transport properties in chemically nonequilibrium neutral gas-mixture flows with electronic excitation is developed. The closed set of governing equations for the macroscopic parameters taking into account electronic degrees of freedom of both molecules and atoms is derived using the generalized Chapman-Enskog method. The transport algorithms for the calculation of the thermal-conductivity, diffusion, and viscosity coefficients are proposed.

Elemental transport coefficients in viscous plasma flows near local thermodynamic equilibrium.

We propose a convenient formulation of elemental transport coefficients in chemically reacting and plasma flows locally approaching thermodynamic equilibrium. A set of transport coefficients for elemental diffusion velocities, heat flux, and electric current is introduced. These coefficients relate the transport fluxes with the electric field and with the spatial gradients of elemental fractions, pressure, and temperature.

Effects of delta sleep-inducing peptide on pre- and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats.

We studied the effect of delta sleep-inducing peptide on GABA receptors of hippocampal and cerebellar neurons in rats. It was shown that delta sleep-inducing peptide considerably and dose-dependently potentiates GABA-activated currents in these neurons and blocks NMDA-activated potentiation in cortical and hippocampal neurons. The peptide modulates activity of presynaptic NMDA receptors, which is seen from changes in (45)Ca(2+) uptake into synaptosomes of the brain cortex after uptake stimulation with glutamate and NMDA.

Nonequilibrium kinetics of a radiative CO flow behind a shock wave.

An investigation is presented of a highly nonequilibrium CO flow with consistently coupled vibrational energy exchanges, chemical reactions, and radiation. A detailed state-to-state model taking into account vibration-vibration, vibration-translation, and vibration-electronic transitions, dissociation-recombination reactions, and radiative transitions between vibrational and electronic states is developed on the basis of kinetic theory methods. A closed set of master equations for vibration-electronic level populations, number densities of atomic species, radiation intensity, temperature, and velocity is derived, and a one-dimensional inviscid carbon monoxide flow behind a plane shock wave is studied numerically.

[Comparative hygienic evaluation of nonionogenic surface-active agents with regard to stability and transformation].

The stability of the surfactants penazoline 10-16 B, neonol AF9-CN, and perfluorodecyl alcohol on boiling, exposure to ozone, ultraviolet and electromagnetic irradiation, biota in the model water reservoir, active sludge in the model air tank was evaluated. The transformation products forming under the influence of different damaging factors were assessed. The comparative hazard of parent compounds and their transformation products on biological test objects was studied.

[The hygienic evaluation of a local unit for sewage treatment].

A complex of hygienic criteria was proposed to assess a Bioclere local unit for sewage treatment. These included: the effects of the organoleptic properties of sewage, better sanitary and chemical parameters, lower levels of inorganic and organic chemicals, surfactants, microbiological parameters, stability of treatment regimens. The Bioclere unit has some advantages over the similar ones and may be useful when an object cannot be connected to the sewage network.

[An experimental validation of the MPEL for the Zharilek mixture and its component constituents].

"Zharilek" preparation MAC in the water reservoirs was approved at the level of 0.01 mg/l. The preparation is referred to the 3rd class of hazard by the complex toxicological study.

[The action on brain functions in white rats of the immunostimulant Freund's complete adjuvant].

The effect of immunostimulator--Freund's adjuvant complete on the nociception and learning of white rats using food-obtaining and avoidance of electric shock techniques has been studied. It has been shown that the adjuvant in doses for active immunization causes itself the expressed changes in animal behaviour. The adjuvant's injections significantly increases the learning ability of animals both with negative and positive reinforcement as compared with control one.

[The convulsive activity of white rats after immunization with a conjugate of sidnofen and serum albumin].

The influence of white rats immunization by a covalent conjugate of serum albumin with sydnophen on the seizure activity in the single and repeated injections of pentylenetetrazole was investigated. The immunization lowered the seizure activity in single injections of threshold doses, (60 mg/kg) of pentylenetetrazole. The repeated daily injections of the drug in subthreshold doses (30 mg/kg) inhibited the process of "kindling" effects formation.