Analysis of multiple biomarkers revealed the size matters of Cu particles for barley response under foliar exposure.

The impact of particle size of engineered nanoparticles (ENPs) on plant response has marginally been investigated under the foliar application so far. Concerning the significance of particle diameter for their properties and interaction with plants, the effect of size should be considered in the analysis of the effect of micronutrient-based ENPs on plants. It is of particular importance for ENPs containing Cu due to plants needing a relatively low amount of this element, thus there is a risk of overdosing during application as a fertilizer or pesticide.

Therapeutic Drug Monitoring of Direct Oral Anticoagulants in Patients with Extremely Low and High Body Weight-Pilot Study.

Phase III clinical trials for individual direct oral anticoagulants (DOACs) contained a limited representation of subjects with abnormal body weight, which were mostly limited to a BMI > 40 kg/m, or body weight > 120 kg for obese subjects, and <50 kg for underweight subjects. Although low or high body weight is not a contraindication to DOACs therapy, it can significantly affect the safety and effectiveness of treatment. Due to the limited amount of clinical data on the use of DOACs in extremely abnormal weight ranges, optimal pharmacotherapy in this group of patients is a matter of controversy.

Transcriptional response of Cu-deficient barley (Hordeum vulgare L.) to foliar-applied nano-Cu: Molecular crosstalk between Cu loading into plants and changes in Cu homeostasis genes.

For safe and effective nutrient management, the cutting-edge approaches to plant fertilization are continuously developed. The aim of the study was to analyze the transcriptional response of barley suffering from Cu deficiency to foliar application of nanoparticulate Cu (nano-Cu) and its ionic form (CuSO) at 100 and 1000 mg L for the examination of their supplementing effect. The initial interactions of Cu-compounds with barley leaves were analyzed with spectroscopic (ICP-OES) and microscopic (SEM-EDS) methods.

The life cycle study revealed distinct impact of foliar-applied nano-Cu on antioxidant traits of barley grain comparing with conventional agents.

Despite that the applicability of Cu-based engineered nanoparticles (ENPs) as an antibacterial and antifungal agent for plant protection has been studied widely, little is known about their role in the improvement of crop yield and quality. Here, a full life study was performed to investigate the nutritional quality and bioactivity of barley grains under foliar application of nano-/microparticulate (nano-Cu, nano-CuO, micro-Cu) and ionic Cu compounds (CuSO, CuEDTA). Hordeum vulgaris L.

Metallic lead (Pb) nanospheres discovered in Hadean and Eoarchean zircon crystals at Jack Hills.

Here, we report small randomly-distributed crystalline lead (Pb) nanospheres occurring in detrital zircon grains obtained from a weakly metamorphosed Archean conglomerate at Jack Hills, Western Australia, making this the third known global example of this phenomenon. They form in zircon crystals ranging from Hadean (> 4 billion years-Ga) to Eoarchean (> 3.6 Ga) in age, but are absent from Paleoarchean (~ 3.

Unveiling of interactions between foliar-applied Cu nanoparticles and barley suffering from Cu deficiency.

The objective of this study was to evaluate nano-Cu-plant interactions under Cu deficiency. Nano-Cu at rates of 100 and 1000 mg L was applied as foliar spray to Hordeum vulgare L. during increased demand for nutrients at tillering stage.

Diverse Partners of the Partitioning ParB Protein in Pseudomonas aeruginosa.

In the majority of bacterial species, the tripartite ParAB- system, composed of an ATPase (ParA), a DNA-binding protein (ParB), and its target sequence(s), assists in the chromosome partitioning. ParB forms large nucleoprotein complexes at (s), located in the vicinity of origin of chromosomal replication (), which after replication are subsequently positioned by ParA in cell poles. Remarkably, ParA and ParB participate not only in the chromosome segregation but through interactions with various cellular partners they are also involved in other cell cycle-related processes, in a species-specific manner.

The Usability of IT Systems in Document Management, Using the Example of the .

Background: In 2016, an IT system was developed at MUL for the documentation of nursing practice. Preparing nursing students for the implementation of eHealth solutions under simulated conditions is crucially important for achieving the digital competencies necessary for health care systems in the future. Scientific evidence demonstrates that the use of an IT system in clinical practice shortens the time required for the preparation of documentation, increases the safety of clinical decisions and provides data for analysis and for the creation of predictive models for the purposes of HB HTA.

The antioxidant defense responses of Hordeum vulgare L. to polycyclic aromatic hydrocarbons and their derivatives in biochar-amended soil.

The recent studies indicated that the biochar (BC) may be a source of polycyclic aromatic hydrocarbons (PAHs) as well as their oxygen, nitrogen, or sulfur-containing derivatives that are considered as more toxic pollutants than their parent compounds. Here, the assessment of the impact of various biochars addition (1% wt.) to soil on barley Hordeum vulgare L.

Cross-examination of engineered nanomaterials in crop production: Application and related implications.

The review presents the current knowledge on the development and implementation of nanotechnology in crop production, giving particular attention to potential opportunities and challenges of the use of nano-sensors, nano-pesticides, and nano-fertilizers. Due to the size-dependent properties, e.g.

Combined effect of nano-CuO and nano-ZnO in plant-related system: From bioavailability in soil to transcriptional regulation of metal homeostasis in barley.

The co-existence of engineered nanoparticles (ENPs) in the environment is an emerging issue remaining poorly investigated. The present study aimed at analyzing the fate of binary mixtures of CuO and ZnO ENPs in a soil-plant system. The ENPs were singly or jointly dosed into soil at 300 mg kg and aged for 7 and 30 days.

The chronic effects of CuO and ZnO nanoparticles on Eisenia fetida in relation to the bioavailability in aged soils.

The bioavailability and bioaccumulation of metal-based engineered nanoparticles (ENPs) in soils need to be evaluated in environmentally relevant scenarios. The aim of this study was an analysis of potentially available metal-component ENPs (nano-ZnO and nano-CuO) in soils. Earthworms (Eisenia fetida) were used to examine the bioaccumulation potential of ENPs.

Thrombocytopenia During Prostacyclin Analogue Therapies of Pulmonary Arterial Hypertension-Possible Pathomechanisms and Implications.

Pulmonary arterial hypertension is a quite rare, but problematic disease in everyday cardiologists' practice. Prostanoids are the most important group of drugs used in this disease. One of the biggest problems encountered during treatment with analogs of prostacyclin is thrombocytopenia.

The effect of pH and ageing on the fate of CuO and ZnO nanoparticles in soils.

The objective of this study was to evaluate the fractionation of ZnO and CuO engineered nanoparticles (ENPs) in soils with a pH adjusted to 4.0, 6.5, and 9.

Pb nanospheres in ancient zircon yield model ages for zircon formation and Pb mobilization.

Nanospheres of lead (Pb) have recently been identified in zircon (ZrSiO) with the potential to compromise the veracity of U-Pb age determinations. The key assumption that the determined age is robust against the effects of Pb mobility, as long as Pb is not lost from the zircon during subsequent geological events, is now in question. To determine the effect of nanosphere formation on age determination, and whether analysis of nanospheres can yield additional information about the timing of both zircon growth and nanosphere formation, zircons from the Napier Complex in Enderby Land, East Antarctica, were investigated by high-spatial resolution NanoSIMS (Secondary Ion Mass Spectrometry) mapping.

Ultrasonographic assessment of articular cartilage of the femoral condyle in patients with an increased Q-angle.

Introduction: The patella is a sesamoid for the quadriceps, which increases its power during knee extension and thus transfers considerable forces. The etiology of patellofemoral pain is multifactorial. In the absence of injury, the commonly accepted hypothesis is associated with increased compression of articulating surfaces.

Metallic lead nanospheres discovered in ancient zircons.

Zircon (ZrSiO4) is the most commonly used geochronometer, preserving age and geochemical information through a wide range of geological processes. However, zircon U-Pb geochronology can be affected by redistribution of radiogenic Pb, which is incompatible in the crystal structure. This phenomenon is particularly common in zircon that has experienced ultra-high temperature metamorphism, where ion imaging has revealed submicrometer domains that are sufficiently heterogeneously distributed to severely perturb ages, in some cases yielding apparent Hadean (>4 Ga) ages from younger zircons.

Binding and spreading of ParB on DNA determine its biological function in Pseudomonas aeruginosa.

ParB protein of Pseudomonas aeruginosa belongs to a widely represented ParB family of chromosomally and plasmid-encoded partitioning type IA proteins. Ten putative parS sites are dispersed in the P. aeruginosa chromosome, with eight of them localizing in the oriC domain.

ALS-Plus syndrome. A clinical and neuropathological case study.

ALS-Plus syndrome occurs rarely and usually presents typical ALS phenotype associated with dementia, Parkinsonism or both. We reported a case of sporadic, definite ALS with pseudobulbar palsy, emotional lability and selective cognitive deficit in the presence of frontal lobe dementia. Neuropsychological tests predominantly demonstrated perserveration and dynamic apraxia, CT and MRI scans showed widened subarachnoideal spaces in the frontal and temporal regions.

Acoustic analysis of dysarthria profile in ALS patients.

Dysarthria is a leading disability in ALS patients with motor neurone degeneration in the bulbar region. Although different approaches have been tried in the past, currently, no test is available to detect and follow the progression of dysarthria. We studied 53 patients with definite (n=27) or probable (n=26) ALS (the bulbar onset group n=15, the limb onset group n=38, mean age 53.

Thermoregulatory dysfunction secondary to acute ethanol poisoning.

Acute ethanol poisoning followed by drugs of abuse and psychiatric disorders is the most common cause of hypothermia. An attempt to evaluate the ethanol poisoning degree considering body temperature, serum osmolality, osmolal gap and ethanol concentration measurements was the aim of study. The lowest body temperature measured using infrared tympanic thermometer--First Temp Genius, Sherwood Medical was noted in the severely poisoned patients and was well correlated with the serum osmolality and with the osmolal gap.

The HsdS polypeptide of the type IC restriction enzyme EcoR124 is a sequence-specific DNA-binding protein.

The HsdS and HsdM polypeptides of the type IC restriction enzyme EcoR124 have been purified independently and used in a set of gel retardation experiments to determine the minimum requirements for sequence-specific recognition of DNA by this enzyme. The HsdS polypeptide alone is able to bind to DNA in a sequence-specific manner. In addition, whilst the presence of the HsdM polypeptide gives rise to a stimulation of DNA binding by the HsdS subunit it is not clear whether, under the conditions of the experiments reported here, the HsdS subunit maintains the same interactions with the HsdM subunits observed in the absence of DNA.

[Effect of resuming work after myocardial infarction on its recurrence and mortality in long-term observations].

60 to 95% pts in the age group below 60 return to work after having* suffered the first M.I. Up to the present moment, it has not been proved whether such return influences in any (positive or negative) way the recurrence of M.

[Hematological studies of the populations of Lower Silesia living in different ecological conditions].

Haematological investigations were carried out in different population groups in Lower Silesia. The total material investigated included 439 men and 229 women. The investigations demonstrated that the haemoglobin level, erythrocyte count haematocrit index were lower in the population of villages lying around copper processing plants.