Publications by authors named "Kushiyasri Karunanithi"
Article Synopsis
- A study was conducted to assess the impact of BCG vaccination on specific eicosanoids in the plasma of healthy elderly individuals before vaccination and at one and six months after.
- The clinical trial, part of efforts to reduce COVID-19's effects on the elderly in India, examines the immunological outcomes linked to BCG vaccination.
- Results showed that BCG vaccination decreased levels of certain eicosanoids like LXA4, PGE2, and Resolvin D1, while increasing LTB4, suggesting its potential role in modifying immune responses and reducing inflammation.
SARS-CoV-2 and latent Mycobacterium tuberculosis infection are both highly co-prevalent in many parts of the globe. Whether exposure to SARS-CoV-2 influences the antigen specific immune responses in latent tuberculosis has not been investigated. We examined the baseline, mycobacterial antigen and mitogen induced cytokine and chemokine responses in latent tuberculosis (LTBI) individuals with or without SARS-CoV-2 seropositivity, LTBI negative individuals with SARS-CoV-2 seropositivity and healthy control (both LTBI and SARS-CoV-2 negative) individuals.
View Article and Find Full Text PDFLatent tuberculosis co-infection is associated with heightened levels of humoral, cytokine and acute phase responses in seropositive SARS-CoV-2 infection.
Anuradha Rajamanickam Nathella Pavan Kumar Chandrasekaran Padmapriyadarsini Arul Nancy Nandhini Selvaraj Kushiyasri Karunanithi
J Infect
September 2021
Article Synopsis
- This study investigates how latent tuberculosis infection (LTBI) affects immune responses in individuals co-infected with SARS-CoV-2.
- The researchers found that LTBI-positive individuals had higher levels of SARS-CoV-2 specific antibodies and enhanced neutralization activity compared to those without LTBI.
- LTBI-positive individuals also showed elevated levels of various cytokines and inflammatory markers, suggesting that LTBI influences immune and inflammatory responses in SARS-CoV-2 infection.