Antifungal Properties of Polycephalomyces nipponicus (Ascomycetes) against Candida albicans: Potential for Novel Therapeutic Development.

Candida albicans has the potential to turn pathogenic and cause mild to severe infections, particularly in people with weakened immune systems. Novel therapeutics are required due to its morphological alterations, biofilm development, and resistance to antifungal drugs. Polycephalomyces nipponicus, a traditional East Asian medicinal fungus, has shown potential as an antifungal agent.

Tyrosine oxime derivatives from the fruiting bodies of basidiomycete .

Three undescribed -prenyl-tyrosine oxime derivatives, serpulanines D-F (), were isolated from natural fruiting bodies of the basidiomycete together with serpulanine C (), and other known compounds (). The structures were elucidated based on NMR spectroscopic and mass spectrometry data. Compounds - were screened for their antibacterial activities against (MRSA and MSSA) and using the agar well diffusion method at 1 mg/mL.

Evaluation and Genome Mining of Bacillus stercoris Isolate B.PNR1 as Potential Agent for Fusarium Wilt Control and Growth Promotion of Tomato.

Recently, strategies for controlling Fusarium oxysporum f. sp. lycopersici (Fol), the causal agent of Fusarium wilt of tomato, focus on using effective biocontrol agents.

Evaluation of Soil Streptomyces spp. for the Biological Control of Fusarium Wilt Disease and Growth Promotion in Tomato and Banana.

Fusarium oxysporum f. sp. lycopersici (Fol) and Fusarium oxysporum f.

Enzyme Inhibition and Antimicrobial Activities of Fractionated Wild Grape ( Planch.) Seed Extracts.

Background And Objective: Study on medicinal plant extract is gradually interested and distributed, especially their biological activities. The present study aimed to determine the enzyme inhibition and antimicrobial activities of the fractionated extracts of wild grape (Ampelocissus martinii Planch.) seeds.

Comparative Study on the Effect of Aqueous and Ethanolic Mycelial Extracts from Polycephalomyces nipponicus (Ascomycetes) against Human Breast Cancer MCF-7 Cells.

Recently, the entomopathogenic fungus Polycephalomyces nipponicus has been determined to be a prolific producer of bioactive compounds that have both antibacterial and antimarial activities, but the anticancer effects of the mycelial extracts have not been well studied. The present study investigates the effects and mechanisms of action of P. nipponicus extracts that are responsible for cell death in the human breast cancer MCF-7 cell line.

Evaluation of Antibacterial and Anticancer Activities of the Medicinal Fungus Ophiocordyceps sobolifera (Ascomycetes) from Thailand.

Eleven strains of an entomopathogenic fungus, isolated and identified as Ophiocordyceps sobolifera, were screened for activity against 5 strains of Gram-negative and 5 strains of Gram-positive bacteria. Four of the isolates, Cod-KK1634, Cod-KK1643, Cod-KS1601, and Cod-SN1626, had activity against the test strains of Grampositive bacteria. Of these 4 extracts, the Cod-KK1643 extract had the lowest minimum inhibitory and bactericidal concentrations.

Colony Characteristics, Nucleoside Analog Profiles, and Genetic Variations of Medicinal Fungus Polycephalomyces nipponicus (Ascomycetes) Isolates from Northeast Thailand.

The entomopathogenic fungus Polycephalomyces nipponicus is known to have activity against human pathogenic bacteria and the malaria pathogen; however, information about its genetic variation is limited. In this study, cicada nymphs infected with entomopathogenic fungi were collected from various locations in the northeast of Thailand. Internal transcribed spacer sequencing was used to identify the fungal pathogen P.

Effects of Ethyl Acetate Extracts from the Polycephalomyces nipponicus Isolate Cod-MK1201 (Ascomycetes) against Human Pathogenic Bacteria and a Breast Cancer Cell Line.

This study aimed to identify a suitable organic solvent for extracting bioactive compounds from Polycephalomyces nipponicus and to evaluate the antibacterial and anticancer activities of the extracts obtained. Only extracts obtained with ethyl acetate exhibited antibacterial activity, so ethyl acetate was chosen for large-scale extraction. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Gram-positive and Gram-negative human pathogenic bacteria of the 3 ethyl acetate-derived extracts-ethyl acetate extract from P.

Isolation of the Entomopathogenic Fungal Strain Cod-MK1201 from a Cicada Nymph and Assessment of Its Antibacterial Activities.

The entomopathogenic fungus Cod-MK1201 was isolated from a dead cicada nymph. Three regions of ribosomal nuclear DNA, the internal transcribed spacers of nuclear ribosomal DNA repeats (ITS), the partial small subunit of rDNA (nrSSU) , and the partial large subunit of rDNA (nrLSU), and two protein-coding regions, the elongation factor 1α (EF-1α), and the largest subunit of the RNA polymerase II (rpb1) gene, were sequenced and used for fungal identification. The phylogenetic analysis of the ITS and the combined data set of the five genes indicated that the fungal isolate Cod-MK1201 is a new strain of Cordyceps sp.

Comparison of mosquito densoviruses: two clades of viruses isolated from indigenous mosquitoes.

We analyzed the phylogenetic tree of densoviruses isolated from indigenous mosquitoes and mosquito cell lines. Our findings suggest two distinct clades of densovirus. The viruses in the first clade were isolated from an indigenous mosquito which had the Aedes aegypti densovirus (AaeDNV) as a representative virus.

Development of SCAR primers based on a repetitive DNA fingerprint for Escherichia coli detection.

The present study aimed to use enterobacterial repetitive intergenic consensus (ERIC) fingerprints to design SCAR primers for the detection of Escherichia coli. The E. coli strains were isolated from various water sources.

New genetic variation of Aedes albopictus densovirus isolated from mosquito C6/36 cell line.

Densovirus (DNV) is a small single-stranded DNA, non-enveloped virus belonging to the subfamily Densovirinae of the Parvoviridae family. This group of invertebrate viruses infects exclusively insects. Two of the major densoviruses, Aedes aegypti (AaeDNV) and Ae.

Heterologously type IV pilus expressed protein of Burkholderia pseudomallei is immunogenic but fails to induce protective immunity in mice.

Burkholderia pseudomallei is the causative agent of melioidosis, a severe disease of humans and animals. At present, no effective vaccine against melioidosis exists. Bacterial type IV pilin proteins have been used successfully as subunit vaccines.