Publications by authors named "Kusalik Boppana"
Inflammatory bowel disease (IBD) is a chronic ailment impacting the digestive system, triggered by an unusual reaction of the immune system. It includes two types of diseases: ulcerative colitis and Crohn's disease. Nonetheless, the diagnosis and evaluation of disease progression in IBD are difficult due to the absence of distinct indicators.
View Article and Find Full Text PDFBariatric surgery, although effective in treating obesity-related comorbidities, rarely results in intussusception, which is a severe complication. This study aimed to enhance clinical practice and establish early diagnosis by elucidating risk factors and management strategies associated with intussusception. We conducted this systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analysis 2020 criteria.
View Article and Find Full Text PDFFebrile seizures (FS) are commonly seen in younger age groups. The cause of seizures is multifactorial, including viral illnesses, certain vaccines such as MMR (measles, mumps, rubella), family history of FS, and certain mineral deficiencies like zinc. Iron deficiency anemia (IDA) is the most common cause of anemia in children of the same age group.
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- Epilepsy is a common neurological disorder marked by recurrent seizures, significantly affecting children, and often requires antiepileptic drugs (AEDs) for treatment, though many cases become drug-resistant.
- This systematic review investigates different types of ketogenic diets (KDs), assessing their effectiveness, safety, and impact on seizure frequency while adhering to PRISMA guidelines and including 11 selected articles from reputable medical databases.
- Challenges like adherence difficulties and the need for family involvement are noted, with a reminder that KD therapy requires careful monitoring and an understanding that success varies among individuals due to diverse seizure types.
The most recent advancements in cancer therapy center on efficiently and conveniently enhancing a patient's natural immune system. Immune checkpoint inhibitors (ICIs) are antibodies that target cytotoxic thymus (T) lymphocyte antigen-4 (CTLA-4) and its receptor. They function by stimulating T-cell activity against malignancies.
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- Heart failure (HF) is a significant health issue globally, leading to high morbidity and mortality rates, which also place a heavy financial strain on health systems.
- Angiotensin receptor-neprilysin inhibitor (ARNI), specifically sacubitril/valsartan, is a newer treatment option for HF, but its effectiveness compared to traditional treatments like ACE inhibitors and ARBs is still being researched.
- A systematic review of recent large-scale clinical trials involving over 17,000 participants showed that sacubitril/valsartan led to better outcomes in reducing HF hospitalizations and preventing renal function decline, without increasing cardiovascular mortality risk.