Publications by authors named "Kusaka M"
Background: The concept of recovery has become internationally widespread. To promote personal recovery of individuals with mental disorders, it is important that they live life on their own terms. Many people with mental disorders wish to build intimate relationships and marry.
View Article and Find Full Text PDFObjectives: The optimal indication and survival benefits of prophylactic urethrectomy (PU) during radical cystectomy remain unclear. Therefore, this study aims to evaluate the impact of urethra-preserving surgery (UPS) on oncological outcome including its recurrence patterns, and to establish an optimal urethral management strategy with a novel UPS technique in the robotic era.
Patients And Methods: We retrospectively analyzed 281 male patients with bladder cancer who received radical cystectomy (RC) (115 with and 166 without PU) at our institutions between 2010 and 2023.
Article Synopsis
- * Results showed that the ERAS protocol significantly shortened hospital stays, improved bowel recovery, and reduced POI in non-frail patients, but it did not have the same benefits for frail patients.
- * The findings suggest that while ERAS is effective for non-frail patients, frail patients might require additional strategies, like prehabilitation, to better manage POI post-surgery.
Article Synopsis
- The study aimed to assess the safety and effectiveness of robot-assisted radical cystectomy with an intracorporeal ileal conduit in older patients (≥75 years) compared to younger patients (<75 years).
- A total of 122 patients were analyzed, showing no major differences in perioperative outcomes except for a longer hospital stay for older patients (19 days vs. 16 days).
- Despite some complications being more frequent in older patients, there were no significant differences in cancer recurrence or survival rates, suggesting that the procedure is safe and effective for older individuals.
Purpose: To investigate the predictors of macular chorioretinal atrophy, consisting of patchy atrophy (PA) at the macula and choroidal neovascularization (CNV)-related macular atrophy (CNV-MA), during treatment with ranibizumab or aflibercept for myopic CNV (mCNV) and its impact on visual outcomes.
Methods: This retrospective study included 82 eyes with treatment-naïve mCNV who were treated with pro re nata injections of ranibizumab or aflibercept.
Results: Nine eyes (11.
Set yogurt's physical characteristics are greatly affected by the homogenization and heat treatment processes. In our previous study, set yogurt treated at 130°C and with the fat particle size reduced to ≤0.6 μm had equivalent curd strength, less syneresis and smoother texture than yogurt treated at 95°C.
View Article and Find Full Text PDFBackground: University of Wisconsin solution (UW) may freeze at temperatures below -0.7 °C, damaging the graft. The present study assessed the effectiveness of the liver graft package protocol, which recommends filling a package with sufficient liquid to prevent grafts from sustaining freezing injury.
View Article and Find Full Text PDFBackground: The interaction between lymph node dissection (LND) during radical cystectomy (RC) and neoadjuvant chemotherapy (NAC) remains unclear. This study aimed to evaluate the role of LND in patients undergoing RC after NAC.
Patients And Methods: We retrospectively analyzed 259 patients with muscle-invasive bladder cancer (MIBC) who underwent RC following NAC at Fujita Health University Hospital and Fujita Health University Okazaki Medical Center between 2010 and 2022.
Article Synopsis
- - The text discusses a clinical trial on machine perfusion for kidney transplants in Japan, aiming to boost the use of this technique due to its potential benefits for organ preservation.
- - Thirteen kidney transplant procedures were performed using a specific machine that maintains optimal conditions for the organs, with details on donor types and recipient demographics highlighted.
- - The results indicated successful preservation with no primary non-functional cases, showing promise for machine perfusion as a method for using marginal donor organs in Japan.
Article Synopsis
- The study explores how using kidney donors after cardiac death (DCD) can address organ shortages and highlights the importance of understanding delayed graft function (DGF), which is a common issue in these transplants.* -
- Researchers analyzed plasma samples from patients who received kidneys from living donors (LD), brain-dead donors (BD), and DCD donors, finding that total cell-free DNA (tCF-DNA) levels were significantly higher in DCD and BD transplants compared to LD transplants.* -
- The study concludes that elevated tCF-DNA levels are associated with DGF and could serve as a predictive biomarker for kidney recovery after DCD transplantation.*
Article Synopsis
- - This study evaluated the risks and benefits of using selective clamping during robot-assisted partial nephrectomy (RAPN) by analyzing 372 patients who underwent the procedure from 2010 to 2021.
- - After matching patients based on their characteristics, the study found that while both clamping methods had similar surgical times and complication rates, the full clamping method resulted in significantly lower estimated blood loss (30 vs. 60 mL).
- - Despite selective clamping having higher blood loss, it did not show any renal functional advantages compared to full clamping based on the preservation of estimated glomerular filtration rate (eGFR) at 6 and 12 months post-surgery.
Article Synopsis
- Previous research indicates that Kyoto University Substances (KUSs) can reduce cell death in glaucoma mouse models by modifying gene expression, particularly affecting retinal ganglion cells.
- The study focused on the genes endothelin-1 (Edn1) and endothelin receptor type B (Ednrb), which were found to be increased by NMDA injury and decreased by KUS treatment.
- Results showed KUSs improved cell viability under stress conditions, and this protective effect was linked to the suppression of endothelin signaling, demonstrating a mechanism through which KUSs may help retinal cells under stress.
Alanine-serine-cysteine transporter 2 (ASCT2) has been associated with increased levels of metabolism in various malignant tumors. However, its biological significance in the proliferation of prostate cancer (PCa) cells remains under investigation. We used the cBioPortal database to assess the effect of ASCT2 expression on the oncological outcomes of 108 PCa patients.
View Article and Find Full Text PDFObjectives: Delta C-peptide derived by the glucagon stimulation test is a reliable value for the evaluation of the pancreatic endocrine function after pancreas transplantation. We examined the associations between delta C-peptide as pancreatic graft endocrine function and donor background factors.
Methods: Sixty-five cases of pancreatic transplantation from brain-dead donors, which were performed in our facility, were enrolled in this study.
BMP3b Is a Novel Antifibrotic Molecule Regulated by Meflin in Lung Fibroblasts.
Am J Respir Cell Mol Biol
October 2022
Article Synopsis
- * Meflin-expressing fibroblasts are resistant to TGF-β-induced fibrogenesis, and the study identified BMP3b as a key downregulated gene in meflin-deficient cells, suggesting it plays an antifibrotic role.
- * Treatment with BMP3b effectively countered TGF-β-induced fibrogenesis, indicating it could be a potential therapeutic target for lung fibrosis treatment.
Article Synopsis
- - The study analyzed 323 patients who underwent robot-assisted partial nephrectomy (RAPN) with two types of CT scans: ultra-high-resolution (UHR-CT) and area-detector CT (ADCT), focusing on perioperative and short-term outcomes.
- - Results showed that the median warm ischemia time (WIT) was significantly shorter in the UHR-CT group (15 min) compared to the ADCT group (17 min), and estimated blood loss (EBL) was also lower in the UHR-CT group (33 mL vs. 50 mL).
- - Despite these benefits, there were no significant differences in short-term kidney function preservation (eGFR) between the
Article Synopsis
- This study assessed the risk factors for postoperative ileus in 78 patients who had robot-assisted radical cystectomy with urinary diversion for bladder cancer during a ten-year period at Fujita Health University.
- Out of the patients analyzed, 25.6% developed postoperative ileus, with notable differences in preoperative Geriatric-8 scores and a history of previous abdominal or pelvic surgeries between those with and without ileus.
- Key independent predictors of postoperative ileus included lower Geriatric-8 scores, delayed mobilization, and slower fluid intake, suggesting that preoperative evaluations and enhanced recovery strategies could improve patient outcomes.
Purpose: The incidence of secondary bladder cancer after treatment for localized prostate cancer (PCa) remains unclear. In this study, PCa cases treated with brachytherapy (BT) were evaluated to assess the incidence of a second malignancy of bladder cancer in a Japanese cohort.
Materials And Methods: Overall, 969 patients treated with BT at our hospital between July 2006 and January 2019 were included in the study cohort.
There are various measures currently in place to prevent the spread of coronavirus (COVID-19); however, in some cases, these can have an adverse effect on the acoustic environment in buildings. For example, transparent acrylic partitions are often used in eating establishments, meeting rooms, offices, etc., to prevent droplet infection.
View Article and Find Full Text PDFBackground: To compare perioperative and long-term oncological outcomes and recurrence patterns between robot-assisted radical cystectomy with intra-corporeal urinary diversion (iRARC) and open radical cystectomy (ORC).
Methods: We retrospectively analyzed 177 bladder cancer patients who received iRARC or ORC at Fujita Health University between 2008 and 2020. Our primary endpoint was long-term oncological outcomes.
Background: Disease progression in castrate-resistant prostate cancer (PCa) is most commonly driven by the reactivation of androgen receptor (AR) signaling and involves AR splice variants including ARV7.
Materials And Methods: We used the ARV7-positive PCa cell line, 22Rv1, to study the relationship of the PCa marker α-methylacyl-CoA racemase (AMACR), AR, and ARV7 in PCa.
Results: Docetaxel addition but not AMACR inhibition decreased the proliferation of 22Rv1 cells.
Background: We previously reported a novel technique using an elastic silicone bowl, which was handmade from a phaco test chamber, to salvage dislocated lenses and perform phacoemulsification and aspiration (PEA) on the bowl. However, creating the bowl was challenging.
Methods: A factory-made elastic silicone sheet (ESS), a ready-to-use alternative for the posterior capsule of the lens, was prepared.
A 63-year-old female with a history of retinal detachment repair with scleral buckle from 28 years prior presented with exposure of the buckle in her right eye. After removing the buckle and anchoring sutures, the operation field was washed with 0.25% polyvinyl alcohol-iodine, vancomycin, and ceftazidime.
View Article and Find Full Text PDFTo evaluate the outcomes of robot-assisted partial nephrectomy (RAPN) in cystic renal tumors. We retrospectively analyzed patients who underwent RAPN for either cystic ( = 46) or solid ( = 271) renal tumors at Fujita Health University between 2010 and 2019. Cystic renal tumors were diagnosed using cross-sectional imaging.
View Article and Find Full Text PDFThis study aimed to investigate risk factors for sarcopenia in community-dwelling older adults visiting regional medical institutions. We retrospectively analyzed medical records of 552 participants (mean age: 74.6 ± 6.
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