Differentiating multiple sclerosis with predominant spinal cord and optic nerve involvement from other autoimmune demyelinating diseases using B cell immunophenotyping and gene expression profiling.

Objective: Multiple sclerosis (MS) may present with predominant involvement of the spinal cord and optic nerve (MS/w-SCON) and mimic other autoimmune inflammatory demyelinating disorders (AIDD) such as neuromyelitis optica spectrum disorder (NMOSD), and relapsing inflammatory optic neuritis (RION). Thus, biomarkers are required for effective differential diagnosis of AIDD.

Methods: Patients with MS/w-SCON (n = 20), MS without involvement of SCON (MS/wo-SCON) (n = 22), NMOSD (n = 16), RION (n = 15) and healthy individuals (n = 21) were included.

Anti-JCV antibody index seroconversion in Turkish multiple sclerosis patients treated with natalizumab.

Background: The anti-JCV antibody index is widely used to monitor multiple sclerosis (MS) patients receiving natalizumab, as seroconversion is linked to an increased risk of progressive multifocal leukoencephalopathy. This study aimed to evaluate the prevalence and risk factors of anti-JCV antibody seroconversion in patients treated with natalizumab.

Methods: We included MS patients exposed to natalizumab treatment for at least one year, with a negative anti-JCV antibody index at baseline, and a minimum of two anti-JCV antibody assessments more than six months apart.

Retinoic acid modulates peripheral blood helper innate lymphoid cell composition in vitro in patients with multiple sclerosis.

This study investigates the frequency and numbers of circulating helper innate lymphoid cells (ILCs) in untreated relapsing-remitting multiple sclerosis (RRMS) patients, focusing on intracellular IL-10 and CCR6 expressions under IL-2, IL-33, and retinoic acid (RA) stimulation in vitro and their associations with clinical features in RRMS. In RRMS patients, ILC1 levels were notably higher upon IL-2 + IL-33 + RA stimulation, while ILC2 levels, particularly the c-Kit ILC2 and CCR6 ILC2 subsets, were significantly lower compared to unstimulated conditions. Additionally, IL-10 ILC1 levels were elevated.

Perceptions of pediatric emergency nurses and parents presenting to the emergency department regarding violence: A qualitative study.

Aim: We aimed to examine in-depth the violence which pediatric emergency service nurses and parents of the children perceive towards them.

Methods: The study was conducted as phenomenological research and 15 pediatric nurses, and 15 parents were included in the pediatric emergency department. The data were analyzed using the thematic analysis method.

Validity and Reliability of the Turkish Version of the Patient-Reported Impact of Spasticity Measure in Multiple Sclerosis.

Background: We aimed to evaluate the validity and reliability of the Turkish version of the Patient-Reported Impact of Spasticity Measure (PRISM-TR).

Methods: Expert opinions and the forward-back translation method were used for linguistic validation. Cronbach α and test-retest analysis were performed for reliability analysis.

The agreement between face-to-face and tele-assessment of balance tests in patients with multiple sclerosis.

Background: To investigate the reliability of balance tests administered using a tele-assessment method in patients with multiple sclerosis (MS).

Methods: The participants were assessed both online and face-to-face. The assessments were performed synchronously by two physiotherapists.

Parenchymal Neuro-Behçet's disease or Comorbid Behçet's disease with multiple sclerosis: A discriminative analysis of a complex clinical entity.

Background: Patients with Behçet's disease (BD) may rarely manifest with cerebral white matter lesions resembling multiple sclerosis (MS). This may result in misdiagnosis due to diagnostic difficulties between parenchymal neuro-BD (pNBD) and MS. This study aims to elucidate the distinguishing features of patients with comorbid BD and MS (BD+MS) in comparison to those with pNBD and MS alone by focusing on clinical and laboratory features.

Prevalence and incidence of multiple sclerosis in Turkey: A nationwide epidemiologic study.

Background: Many studies on multiple sclerosis (MS) reveal different prevalence and epidemiologic results.

Objectives: In this study, we aimed to determine the epidemiologic profile of MS using official health records in Turkey.

Methods: Patients diagnosed with MS from the official health data of the Ministry of Health, representing the entire population of Turkey, were included in the study.

Earthquake Experiences of Nursing Students Residing in Earthquake Zone, the Disaster of the Century: A Qualitative Study.

This study was carried out to examine the experiences of nursing department students regarding earthquakes with a phenomenological approach. The type of research is phenomenological research, one of the qualitative research methods. The research was carried out with 22 nursing students who experienced the earthquake in the Turkey earthquake on February 6, 2023.

Diffusion Tensor Imaging in Parenchymal Neuro-Behçet's Disease.

Introduction: Parenchymal Neuro-Behçet's disease (p-NBD) usually presents with a characteristic lesion in the mesodiencephalic region. However, there is a lack of information regarding the axonal integrity of normal-appearing white matter in p-NBD. Diffusion tensor imaging (DTI) is based on the properties of diffusivity and anisotropy that indicate the integrity of axons.

The effectiveness of sexual health and development education given to children with intellectual disabilities: A randomized controlled study.

Purpose: The purpose of this study is to determine the effectiveness of an educational program implemented to support the sexual health and development of children with intellectual disabilities, using the Mastery Learning Model, on their knowledge of sexual health and development, as well as on their mothers' awareness of their children's sexual development.

Method: This study was conducted as a randomized controlled trial with 48 children who have intellectual disabilities, divided into two groups: an education group (n = 24) and a control group (n = 24). The program implemented was a sexual health and development education program based on the Mastery Learning Model.

[Cerebellar antibodies in post-stroke sera of acute ischemic stroke patients].

Background And Purpose:

Concomitant Crohn's Disease and Anti-Glutamic Acid Decarboxylase (GAD)-Associated Autoimmune Encephalitis: A Case Report.

Crohn's disease is an inflammatory, autoimmune disorder that predominantly affects the intestines but can also affect extraintestinal organs. Certain neurological conditions, such as autoimmune encephalitis, can develop along with this disease. In this case report, we present a case of anti-glutamic acid decarboxylase (GAD) antibody-associated autoimmune encephalitis that occurred shortly after the diagnosis of Crohn's disease and was unrelated to the treatment and nutritional deficiencies.

The effect of baby-led weaning and traditional complementary feeding trainings on baby development.

Purpose: The aim of this study was to evaluate the risks of self-feeding, transition to early solid food and family meals, choking risk, anemia risk and obesity risk in 6-12-month-old infants who were introduced to complementary feeding using the traditional complementary feeding (TCF) and baby-led weaning (BLW) methods/training.

Design And Methods: Mothers of infants who had not yet transitioned to complementary feeding were included in this randomized study. The mothers of 62 infants included in the study were randomized into the intervention groups as TCF and BLW, classified according to the number of children and education level.

The Effect of Smoking on Inactivated and mRNA Vaccine Responses Applied to Prevent COVİD-19 in Multiple Sclerosis.

Introduction: Coronavirus disease 2019 (COVID-19) is the biggest health challenge of recent times. Studies so far reveal that vaccination is the only way to prevent this pandemic. There may be factors that decrease or increase vaccine effectiveness.

Chloride intracellular channel protein-1 (CLIC1) antibody in multiple sclerosis patients with predominant optic nerve and spinal cord involvement.

Introduction: Antibodies to cell surface proteins of astrocytes have been described in chronic inflammatory demyelinating disorders (CIDD) of the central nervous system including multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Our aim was to identify novel anti-astrocyte autoantibodies in relapsing remitting MS (RRMS) patients presenting predominantly with spinal cord and optic nerve attacks (MS-SCON).

Methods: Sera of 29 MS-SCON patients and 36 healthy controls were screened with indirect immunofluorescence to identify IgG reacting with human astrocyte cultures.

Serum CXCL5 as a biomarker in multiple sclerosis and neuromyelitis optica spectrum disorder.

Objective: Our aim was to determine whether serum C-X-C motif chemokine 5 (CXCL5) may serve as a diagnostic biomarker for relapsing-remitting multiple sclerosis (RRMS) as well as a marker that can be used to predict treatment response.

Methods: CXCL5 levels were measured by ELISA in sera of 20 RRMS patients under fingolimod treatment, 10 neuromyelitis optica spectrum disorder (NMOSD) patients, 15 RRMS patients presenting predominantly with spinal cord and optic nerve attacks (MS-SCON), and 14 healthy controls.

Results: Fingolimod treatment significantly reduced CXCL5 levels.

The relationship between the nutritional literacy level and heart health attitudes of adolescents.

Purpose: It was aimed to evaluate the effect of adolescents' nutritional literacy level on their heart health attitudes.

Methods: This is a descriptive and cross-sectional study. Data from 416 adolescents were obtained in the study.

Serum IgG of patients with relapsing inflammatory optic neuropathy immunoreacts with Sox2-positive glial cells of the optic nerve.

Background: Given the significance of glial cells in maintenance of neurons, antibodies directed against glial cells of the optic nerve might reasonably be expected to have a pathogenic impact in relapsing inflammatory optic neuropathy (RION).

Methods: We investigated IgG immunoreactive with the optic nerve tissue by indirect immunohistochemistry using sera of 20 RION patients. Commercial Sox2-antibody was used for double immunolabeling.

Retrospective analysis of effectiveness of fingolimod in real life setting in Turkey (REFINE).

Background: During multiple sclerosis (MS) treatment different modes of action such as lateral (interferon beta to glatiramer acetate or glatiramer acetate to interferon beta) or vertical (interferon beta/glatiramer acetate to fingolimod) drug switch can be performed. This study aims to investigate the clinical effectiveness of switching from the first-line injectable disease modifying treatments (iDMTs) to fingolimod (FNG) compared to switching between first-line iDMTs.

Methods: This is a multicenter, observational and retrospective study of patients with relapsing-remitting MS who had lateral and vertical switch.

Postoperative recovery in children: Turkish cross-cultural adaptation.

Background: Postoperative recovery is an individual process involving subjective experiences. The fact that children still experience high rates of complications associated with surgery requires the discovery of new evaluation methods. No studies in Turkey have reported a measurement instrument evaluating postoperative recovery in children.

Schoolchildren's Attitudes Toward Covid-19 Measures Scale: A Scale Development Study.

For schools and academic studies to continue, children as well must adhere to the measures taken to prevent the spread of Covid-19. The aim of this study was to develop a scale to assess schoolchildren's attitudes toward Covid-19 measures. The sample of this study, which was designed in a methodological type, consisted of 205 children.