Publications by authors named "Kurtis Garbutt"

Article Synopsis
  • The Human Endometrial Cell Atlas (HECA) is a comprehensive single-cell reference atlas derived from 313,527 cells, profiling endometrial samples from 63 women, both with and without endometriosis.
  • HECA not only categorizes known cell types but also identifies new ones, utilizing advanced techniques like spatial transcriptomics and validation through an independent single-nuclei dataset.
  • The findings reveal significant cellular interactions in the endometrium, suggest potential dysregulation of specific cell types in endometriosis, and position HECA as a crucial tool for understanding endometrial health and related disorders.
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Introduction: Chronic pelvic pain (CPP) is a common condition affecting up to 26.6% of women, with many suffering for several years before diagnosis and/or treatment. Its clinical presentation is varied and there are frequently comorbid conditions both within and outside the pelvis.

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Endometriosis is a chronic condition affecting ~10% of women globally. Little is known about the impact of the coronavirus disease 2019 (COVID-19) pandemic on their care. This brief report is aimed to explore the impact of COVID-19 on the care of people with endometriosis around the world, their priorities in relation to their clinical care during and coming out of the pandemic, and whether they believed that endometriosis makes them more vulnerable to COVID-19.

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Introduction: Millions of women suffer from the consequences of endometriosis and uterine fibroids, with fibroids the cause for over 50% of hysterectomies in the USA, and direct costs for their treatment estimated at between US$4 and US$9 billion. Endometriosis commonly affects millions of women worldwide predominantly during reproductive age, with severe menstrual and non-menstrual pain and subfertility the main symptoms. Due to the 'unhappy triad' of endometriosis-lack of awareness, lack of clinically relevant biomarkers and the unspecific nature of symptoms-women wait on average for 8-12 years before the definitive endometriosis diagnosis is made.

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