Voxel-based tumor dose correlates to complete pathologic necrosis after transarterial radioembolization for hepatocellular carcinoma.

Purpose: The transarterial radioembolization (TARE) dose is traditionally calculated using the single-compartment Medical Internal Radiation Dose (MIRD) formula. This study utilized voxel-based dosimetry to correlate tumor dose with explant pathology in order to identify dose thresholds that predicted response.

Methods: All patients with HCC treated with TARE using yttrium-90 [Y] glass microspheres at a single institution between January 2015 - June 2023 who underwent liver transplantation were eligible.