Nanosecond fluorescence studies of noncovalent interaction of monomeric and dimeric intercalators with DNA.

The noncovalent interaction of 2-aminodipyrido[1,2-a:3',2'-d]imidazole (Glu-P-2) and its derivatives, which are potent mutagens isolated from L-glutamic acid pyrolysate, with calf thymus DNA was studied by steady-state and nanosecond fluorescence spectroscopies. The fluorescence of these compounds exhibits static quenching by noncovalent interaction with DNA. Fluorescence lifetimes of the free and intercalated states of these compounds were determined to be 9-10 and 0.

Congenital anaplastic ependymoma: a case report of familial glioma.

A congenital anaplastic infratentorial ependymoma, occurring in a female infant whose sister also died of brain tumor, is described. The tumor, located in the cerebellum and the fourth ventricle, is characterized by predominantly undifferentiated neuroepithelial cells associated with numerous mitoses, and partially of the cells demonstrating differentiation into ependymal cells and astrocytes. Of special interest is the fact that the elder sister of the patient had also died of a congenital glioma located in the cerebellum and the fourth ventricle, which leads to the discussion about the influences of genetic factors in the development of the familial gliomas as well as about the histogenesis of the tumor examined.

[Clinical experience with cefoxitin in the field of gastrointestinal surgery].

A total of 20 patients involved in gastrointestinal surgery was treated with cefoxitin (CFX). Ten patients were treated for postoperative infections and the other 10 patients were given CFX to prevent postoperative infections. The following results were obtained: In 10 patients treated for postoperative infections, 5 responses were judged "excellent", 1 "good", 2 "fair", 1 "poor" and 1 "unknown".

Effects of aspirin, prednisolone and indomethacin on nephrotoxic serum nephritis in the rat.

1 The effects of aspirin, prednisolone, and indomethacin on nephrotoxic serum nephritis in rats was studied. The nephritis was induced by a single intravenous injection of nephrotoxic serum (NTS, rabbit anti-serum against the water-soluble renal antigen of the rat). The injection of NTS induced the heterologous phase of proteinuria (within a day after NTS injection) and then the autologous phase (5 to 7 days after NTS injection).