[Interaction of active chlortriazine dyes with blood proteins].

The study was undertaken to analyze the capacity of organic active chlorotriazine pigments to make contact with blood serum proteins. It was established that pigment toxicity was inversely correlated to the capacity of making contact with blood serum proteins (r = 99%) and directly correlated to the capacity of making contact with albumin (r = 96%).

[Studies of the dependence of alkoxycyanodiphenyl toxicity on structure with the aim of health-related group standardization].

The article presents results of toxicity and hazard effects studies of alcoxicyandiphenyl CnH2n+ 1OC12H8CN with n = 1-8, octilcyandiphenyl and octildiphenyl. Toxicity parameters were established in animal tests and on isolated mitochondria, and inhibiting concentrations were calculated. Correlation was established between the alcoxicyandiphenyl detainment in high-performance liquid chromatography and the inhibition rate constant.

[Use of metabolic and pathogenetic criteria in group standardization of organically active chlortriazine dyes].

The article presents research data related to the biotransformation, intoxication mechanisms and pathogenic properties of chlortriazine dye-stuffs. All the dye-stuffs studies were characterized by similar intoxication properties and pathogenesis, and were related to the 3rd class of hazardous substances. The MAC for the organic chlortriazine dye-stuffs constituted 2 mg/m3.

[Substantiation of group MPEL for dispersive anthraquinone dyes].

The article presents results of the toxicological studies of 65 replaced anthraquinones: amino-, diamino-, haloido-, hydro- and oxianthraquinones. A similar polytropic toxic action was identified. MACs for anthraquinones, alpha-aminoanthraquinones and K-type dispersal dye-stuff were established at 5 mg/m3.

[Problems related to regulation of toxic substances].

Intensification of chemical load on humans and nature requires a complex approach to regulation of hazardous substances. Extensive setting-up of sanitary standards has no significant positive effect on natural and technological environment. Due to more thorough approaches to research it is necessary to establish MACs for major pollutants.

[Use of the data of quantitative analysis of organo-systemic distribution of tumors in the evaluation of real hazards of chemical carcinogens].

The study was concerned with objective criteria for identification of actual carcinogenic hazards. It used quantitative analysis data on morphologic structures of tumors induced in 12565 albino noninbred rats in the course of carcinogenicity evaluation of 112 chemical agents. The totality of all the data were analyzed versus morphologic parameters of tumors and carcinogenicity of the agents.