[New approaches to the evaluation of the cholesterol content of plasma lipoprotein fractions in normo- and hyperlipoproteinemias].

The examination of 1073 males ranging in age from 40 to 59 living in Moscow and Leningrad, and of 146 patients with ischemic heart disease showed a decrease in the alpha-lipoprotein cholesterol level and an increase in the cholesterol content of atherogenic fractions (beta- and pre-beta-lipoproteins) in individuals with ischemic heart disease in the absence of hyperlipoproteinemia (HLP). In combination of ischemic heart disease with hyperlipoproteinemia these changes are pronounced to a larger degree. From the analysis of the results of the studies it is suggested that the coefficient (see article) is determined to reveal disorders in lipoprotein metabolism particularly in the absence of hyperlipoproteinemia.

[Phospholipid composition of high density lipoproteins in hyperalphalipoproteinemia].

Content of lecithin as related to the total content of phospholipids was increased in alpha-lipoproteins of healthy men with hyper-alpha-lipoproteinemia (concentration of cholesterol exceeded 72 mg% in the lipoproteins). The alpha-lipoproteins accumulated considerably more free cholesterol than its esters; this caused a decrease in the molar ration "phospholipids/free cholesterol". The surface of phospholipid-cholesterol monolayer of alpha-lipoproteins is apparently responsible for retaining of increased amounts of cholesterol in the complex as well as for participation of these structures in enzymatic reactions in blood serum.