[Effectiveness of combined use of a lipid peroxidation inhibitor and a lymphatic drainage stimulant in intensive care of acute myocardial infarct].

The efficacy of intensive care for acute myocardial infarction making use of mannitol and vitamin E was under study. The results evidence a marked clinical effect of both the drugs. ECG demonstrates that in the majority of cases the necrotic process is arrested and no grave complications develop after such treatment, and the ECG parameters normalize.

[Stimulation of the lymphatic drainage in intensive care of acute myocardial infarct].

Under study was reogluman efficacy in the acute period of myocardial infarction. Timely administration of the drug to myocardial infarction patients was conductive to reduction of the duration and intensity of the painful syndrome, was associated with a reduction and even disappearance of congestion in the lungs within the first 2 days. These changes were paralleled by a more rapid normalization of the activities of all the blood serum lysosomal enzymes in the patients treated with reogluman as against the reference patients.

[Use of rheogluman in the acute period of myocardial infarction].

The efficacy of rheogluman was evaluated in 55 patients with acute myocardial infarction. ECG mapping recordings in 35 leads showed that an earlier positive dynamics in sigma ST, sigma Q, and sigma R was significantly observed in patients treated with rheogluman than in untreated patients. These data indirectly indicated a reduction in the ++peri-infarct zone in the acute period of myocardial infarction.

[The efficacy of the combined use of a lipid peroxidation inhibitor and a stimulator of the lymphatic drainage of the heart in the treatment of the acute period of myocardial infarction].

The effect of combined use of mannitol and alpha-tocopherol on the course and outcome of acute myocardial infarction has been studied. The results have shown that these drugs have a marked clinical effect. The ECG findings show that in the majority of cases the drugs prevented further development of necrotic process and the onset of life-threatening complications and accelerated normalization of the ECG parameters.

[Effect of lymph-stimulating drugs on the clinical manifestations and parameters of lipid metabolism in patients with post-infarction cardiosclerosis and angina pectoris].

As many as 64 patients with coronary heart disease (CHD) were examined. They were divided into 3 groups: (1) control subjects; (2) patients on supplementary rheogluman and (3) those on supplementary haemodesum (neocompensan). Their status was assessed from the frequency and intensity of anginal attacks, the magnitude of changes in lipid metabolic parameters prior to and following the therapy.

[Laser seromyotomy of the stomach in duodenal ulcers].

The use of laser surgical equipment permits to simplify considerably a method of gastric seromyotomy. On the basis of the results of treating 38 patients, the optimal parameters of laser energy, used in dissection of the gastric wall, are recommended, the advantages and shortcomings of the different sources of radiation are studied.

[Use of carbon dioxide laser in emergency surgery of the extrahepatic bile ducts].

The principles of surgical techniques of operations with the use of carbon dioxide laser were developed on basis of the authors' personal experience of 8 years in surgical interventions on 65 patients. The stages of the operative approach, cholecystectomy, choledochotomy, +choledocho-duodeno-anastomosis, papillosphincterotomy, and sterilization of the operative wound and intraabdominal abscesses are illustrated by professionally drawn illustration-diagrams. Laser separation of the gallbladder from the liver takes 220 +/- 35 sec, laser hemostasis and cholestasis of the gallbladder bed--245 +/- 40 sec, laser choledochotomy--17 +/- 8 sec, laser duodenotomy--33 +/- 9 sec.

[Free iron in bacteria].

Free iron content has been estimated in autotrophic and heterotrophic bacteria. It constituted 40-50 micrograms/g dry weight as compared to 15 micrograms/g dry weight in animal cells. A method for estimation of free iron has been proposed.

[A method of laser seromyotomy of the stomach].

A technique of laser seromyotomy was developed as a method for vagus denervation for the treatment of gastroduodenal ulcers. Soviet Raduga neodymium YAG laser and foreign Medilaz and Flexilas units were employed as sources of laser irradiation. The operation was performed in the 'contact scalpel' mode with the use of Soviet sapphire tips.

[Experimental substantiation of the use of CO2 laser radiation for preventing suppuration of the surgical wound].

It was revealed, that irradiation in the experiment of the spore-forming and non-spore-forming microbial cultures, irrespective of the density of growth, was accompanied by their complete destruction in density of radiant energy of the "Scalpel-1" CO2-laser equal to 32.2 J/cm2 (power density--32.2 W/cm2) and more, and exposure for 1 s.

[Iron as an inducer of nitric oxide formation in the animal body].

Citrate iron complex injections to mice or rats resulted in the nitric oxide formation detected by nitric oxide binding to iron-diethyldithiocarbomate complexes. The mononitrosyl iron complexes formed were paramagnetic and EPR active. The maximal nitric oxide concentrations in rat livers were 15-20 nm per gram of tissue.

[The effect of thiol compounds and iron on formation of nitric oxide from nitroprusside and nitroglycerin].

Some thiol-containing substances 5-Na-thiosulfate, cysteine, reduced glutathione and reducing agent Na-dethionite were shown to elevate formation of nitric oxide from both Na-nitroprusside and nitroglycerol in water solutions, especially if Fe2+ was added into solution of nitroglycerol. Nitric oxide developed was maintained in solutions in the complexes containing water soluble dinitrosyl iron and thiol derivatives. Release of nitric oxide from nitroprusside and nitroglycerol in animals was caused by similar reactions.