COMPARATIVE PHARMACOECONOMIC ANALYSIS OF SELF-CONTROL OF DIABETES MELLITUS USING GLUCOMETERS.

Objective: The aim: To pharmacoeconomic analysis of direct medical costs for self-control of diabetes in Ukraine, Moldova and Georgia. Our observational, cross-sectional study aims at finding out the real costs of covering expenses in order to make decisions on the reimbursement of self-control means.

Patients And Methods: Materials and methods: 1) International and national clinical guidelines for diabetes; 2) information about the prices of glucometers, test strips from online pharmacy services.

RESOLUTION OF NATIONAL ADVISORY BOARD.

On October 2, 2020, by Novo Nordisk initiative, an expert council was held in Tbilisi, Georgia, dedicated to the problems of introducing innovative insulin therapy on the example of insulin degludek into the clinical practice. The council chaired by prof. R.

SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR CONCENTRATION DECREASES IN CORRELATION WITH GLYCATED HEMOGLOBIN LEVELS IN PATIENTS WITH TYPE 2 DIABETES.

Our aim was to compare serum vascular endothelial growth factor (VEGF) level in type 2 diabetes mellitus (T2DM) patients with comorbid OSA at screening and 6 month follow up visits. In the prospective cohort study following data were collected at screening visit: medical anamnesis; demographic and anthropometric data; Epworth sleepiness score data; laboratory (serum VEGF, complete blood count, biochemistry, immunology, complete urine test, including microalbuminuria) and instrumental investigation data (fundoscophy, laboratory polysomnography). At 6 months follow up visit we evaluated anthropometric data; Epworth sleepiness score; serum VEGF.

CONNECTION BETWEEN SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR LEVELS AND SEVERITY OF MICROANGIOPATHY IN PATIENTS WITH TYPE 2 DIABETES AND OBSTRUCTIVE SLEEP APNEA.

Our aim was to evaluate the serum vascular endothelial growth factor (VEGF) level in type 2 diabetes patients with comorbid obstructive sleep apnea (OSA) and to compare it in connection with diabetic retinopathy and chronic kidney disease severity. In the prospective cohort study following data were collected: medical anamnesis; demographic and anthropometric data; laboratory (serum VEGF, complete blood count, biochemistry, immunology, complete urine test, including microalbuminuria) and instrumental investigation data (fundoscophy, laboratory polysomnography). From 232 analyzed patients 54 (23.

HIGH MICROANGIOPATHY PREVALENCE IN OBSTRUCTIVE SLEEP APNEA COMORBID TYPE 2 DIABETES PATIENTS.

Our aim was to study OSA prevalence in patients with T2DM referred to the ,,Diacor'' and to evaluate the microangiopathy rate among this two groups. Data were obtained from T2DM patients enrolled in a prospective, cohort study. The study was being carried out in the clinic ,,Diacor'' Tbilisi, Georgia.

[Saturin - effective vegetative remedy in treatment of type 2 diabetes mellitus].

A chemical investigation of plant Satureja hortensis L. - garden savory (GS) has been carried out. It is established that the GS is rich in phenolic compounds.

[Psychopathologic peculiarities in patients with diabetes mellitus and non-proliferative retinopathy].

The aim of the present work was to study clinical course of depression in patients (pts) with diabetes mellitus (DM) and non-proliferative retinopathy (NPR). In total, 250 pts with DM were included into the study, and more separated into 2 groups (Gr): Gr.1 (n=115)--pts with DMT1 and DMT2 without NPR; mean ABP - SBP < or = 130 mmHg/DBP < or = 85 mmHg.

[Positive effects of angiotensin [corrected] receptor blockers on the course of microvascular complications of diabetes mellitus].

The aim of the research was to evaluate some clinical and hemodynamic characteristics in patients with diabetes mellitus type 1 and type 2 (DM type 1 and DM type 2), to diagnose diabetic retinopathy (DR) on early stage of its development for the correction of the disease by treating with angiotensin II type 1 receptor blocker (AT I)--Candesartan. Totally 250 patients (pts) with DM type 1 and DM type 2 were studied; they were divided into 3 groups (Gr.): Gr.

[Characteristic changes of skin and its accessories in type 2 diabetes mellitus].

The different changes are seen on skin and it's accessories in Diabetes Mellitus, some of which represent the prognostic indicator of complicated diabetes and some directly contribute in development of them. Numerous problems concerned with the diabetic foot could be avoided due to early detection and treatment of these changes. The objective data on foot examination of 195 patient with Type 2 Diabetes Mellitus were analyzed considering the grade of severity of Diabetic Peripheral Neuropathy (DPN).

Twinning project: Israel and Georgia--the birth of a diabetes-in-pregnancy centre in Georgia.

Aims: To determine the effectiveness of a joint Israeli-Georgian twinning project aimed at introducing modern methods of perinatal care to Georgian women with pregestational diabetes mellitus.

Methods: A Diabetes-in-Pregnancy Centre was established in Georgia (in the former USSR). Thirty-two women with Type 1 diabetes mellitus participated in the first stage of the study (January 1997-June 1998).

[Rationale for using kinin system inhibitors in patients with acute ischemia and infarction of the myocardium during the prehospital phase].

The paper discusses if it is advisable to use kallikrein-kinin system inhibitors earlier. A total of 122 patients with acute ischemia and infarction of the myocardium were studied. Contrykal and heparin infused in the prehospital period, followed by hospital treatment are optimal to prevent vascular wall lesions, maximally retain retrograde blood flow, and substantially reduce the size of myocardial infarction.

[Clinical course and the effectiveness of conservative treatment of prolactin-secreting pituitary adenoma].

Forty-eight women with prolactin-secreting adenomas of the hypophysis and 22 patients with suspected microadenomas, aged 16 to 38, were examined. The highest blood prolactin levels and the most manifest symptoms were revealed in the patients with x-ray evidence of hypophyseal macroadenoma. Prolactin levels were lower, though still elevated, in the cases with small adenomas.

[Control and correction of the blood sugar in diabetes with concomitant ischemic heart disease using the artificial beta-cell apparatus employing glucose oxidase as the enzyme].

The apparatus "Artificial Beta-Cell" or "Biostator" was used in treatment of 115 patients with diabetes mellitus and concomitant ischemia of the heart. At the same time 30 patients with diabetes mellitus and ischemia of the heart were treated for diabetes mellitus with the routine methods. Hormones such as ACTH, STH, hydrocortisone, immunoreactive insulin and S-peptide, lipid metabolism and glycosylated hemoglobin were investigated in the time course of the treatment.

[Effect of 24-hour intravenous administration of nitroglycerin on the status of the focus of a lesion in patients with an acute myocardial infarct].

Nitroglycerin was drip-infused for 24 hours to 35 patients with acute myocardial infarction. Thirty-three patients were taken as controls. Intergroup comparisons were made of the patterns of precordial cartograms from 35 leads and serial measurements of plasma MB CPK activity.

[Hypermyoglobinemia and creatine phosphokinase MB activity as signs of combined myocardial lesion and acute cerebral circulatory disorder].

In order to detect simultaneous damage to the myocardium in cerebral stroke the authors radioimmunoassayed myoglubin and activity of the heart fraction of creatine phosphokinase MB (CP K MB) in the blood serum of 22 patients. Hypermyoglobinemia and elevated activity of CP K MB were revealed in almost all cases of hemorrhagic stroke (15 patients) whereas in patients with ischemic stroke they were identified far less frequently. Thus, hypermyoglobinemia and the activity of CP K MB correlate with the macro- and microscopic picture of myocardial damage and may serve as its diagnostic criteria when both the clinical picture and ECG findings prove uninformative.

[Computer analysis of the ECG during physical exercise].

Treadmill tests were performed in one hundred men below 60, with computerized assessment of their ECG data. Reduced R wave amplitude from lead V5 at maximum exercise was only noted in subjects showing no electrocardiographic evidence of ischemia. Increased R wave from lead V5 was regarded as cardiac dysfunction in response to exercise, which, in the presence of ischemic ECG changes, preceded the development of pathologic ST depression.