[Polymorphism Gly460Trp of alpha-adducin gene and predisposition to essential hypertension. The role of gene-environment interactions in the development of the disease in Russian population].

In this study we for the first time in Russian population elucidated association between G460W polymorphism of -adducin gene (ADD1) and risk of development of hypertensive disease (HD). DNA samples from 205 patients with HD and 207 healthy nonrelated individuals of Russian nationality were genotyped for G460W polymorphism of ADD1 gene by polymerase chain reaction and restriction analysis. We detected no statistically significant differences between groups of healthy people and patients with HD.

[A protective effect of GLY272SER polymorphism of GNB3 gene in development of essential hypertension and its relations with environmental hypertension risk factors].

Aim: To study associations of C825T (rs5443) and G272S (rs16932941) polymorphisms of GNB3 gene in Russian population of the Central Chernozem region with essential hypertension (EH) risk; to elicit the role of environmental risk factors in realization of EH predisposition in this gene genotypes carriers.

Material And Methods: We studied DNA samples obtained from 205 EH patients and 207 healthy individuals. EH patients were treated in Kursk hospitals.

[Racial and population variability of phenotypic (cranial) characters in the common shrew Sorex araneus L., 1758].

Variability of the cranial properties of chromosomal races Serov, Manturovo and Pechora of the common shrew were studied. A consistent increase of scull size in the Serov race with moving from the plain to highlands and a skull size decrease from low to high latitudes was detected. Interpopulation variability among different races was shown to be comparable with interracial variability or to exceed it.

[Dynamics of clinical hormonal indices in patients with reactive depressions].

Using radioimmunoassay the authors studied the patterns of plasma levels of cortisol, insulin, triiodothyronine, and thyroxine in patients with acute and protracted reactive depressions. The patients had higher cortisol levels and lower immunoreactivity of the other three hormones as compared to a group of healthy donors. Patients with acute depressions had higher values of cortisol than those with protracted ones.

[Indices of autoimmunity in schizophrenic patients with an unfavorable course after long-term treatment with neuroleptics].

The authors examined 176 patients with schizophrenia running an unfavourable course, treated with neuroleptics for a long time; 20 oligophrenics on prolonged neuroleptic therapy and 47 healthy subjects. The immunological status of the patients was characterized by high neutrophil damage in the presence of a complex of brain antigens, in particular those of the subcortical area (trunk and optic tuber), marked formation of hemolytic plaques, inhibition of spontaneous rosette-formation, low antithymic activity of the serum, and by a slightly elevated level of blood histamine. Administration of chlorpromazine in different concentrations led to a stimulation of plaque formation and inhibition of rosette-formation.