Synthesis, Characterization, and Evaluation of Silver Nanoparticle-Loaded Carboxymethyl Chitosan with Sulfobetaine Methacrylate Hydrogel Nanocomposites for Biomedical Applications.

In this study, nanocomposites of AgNPs encapsulated in carboxymethyl chitosan (CMCS) with sulfobetaine methacrylate (SB) hydrogel (AgNPs/CMCS-SB) were synthesized. The UV-Vis spectra indicated the presence of AgNPs, with a broad peak at around 424 nm, while the AgNPs-loaded CMCS-SB nanocomposite exhibited absorption peaks at 445 nm. The size and dispersion of AgNPs varied with the concentration of the AgNO solution, affecting swelling rates: 148.

Multicolor emission-based nitrogen, sulfur and boron co-doped photoluminescent carbon dots for sequential sensing of Fe and cysteine: RGB color sensor and live cell imaging.

Herein, a simple hydrothermal synthesis is used to prepare multiple heteroatom-doped photoluminescent carbon dots (CDs) from thiourea (N and S source) and boric acid (B source) as precursors. The optical and physicochemical properties of the as-synthesized NSB-CDs were studied using UV-Vis, photoluminescence, TEM, FT-IR, XRD, Raman, and XPS analyses. The NSB-CDs exhibited excellent stability, high photostability, pH, and ionic strength tolerance; they retained their excellent stability independent of excitation.

Nitrogen and sulfur co-doped photoluminescent carbon dots for highly selective and sensitive detection of Ag and Hg ions in aqueous media: Applications in bioimaging and real sample analysis.

In this study, we report the synthesis of photoluminescent (PL) nitrogen (N) and sulfur (S) co-doped carbon dots (NS-CDs) from nitazoxanide and 3-mercaptopropionic acid as a precursors via a one-pot hydrothermal methods. N and S co-doped materials allows more active sites in the CDs surface resulting in an enhancement of their PL properties. NS-CDs show bright blue PL, excellent optical properties, good water solubility, and a high quantum yield (QY) of 32.

Tenofovir antiviral drug solubility enhancement with β-cyclodextrin inclusion complex and study of potential inhibitor against SARS-CoV-2 main protease (M).

Tenofovir (TFR) is an antiviral drug commonly used to fight against viral diseases infection due to its good potency and high genetic barrier to drug resistance. In physiological conditions, TFR is less water soluble, more unstable, and less permeable, limiting its effective therapeutic applications. In addition to their use in treating the Coronavirus disease 2019 (COVID-19), cyclodextrins (CDs) are also being used as a molecule to develop therapies for other diseases due to its enhance solubility and stability.

SARS-CoV-2 main protease (3CL) interaction with acyclovir antiviral drug/methyl-β-cyclodextrin complex: Physiochemical characterization and molecular docking.

During the current outbreak of the novel coronavirus disease 2019 (COVID-19), researchers have examined several antiviral drugs with the potential to inhibit the proliferation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The antiviral drug acyclovir (AVR), which is used to treat COVID-19, in complex with methyl-β-cyclodextrin (Mβ-CD) was examined in the solution and solid phases. UV-visible and fluorescence spectroscopic analyses confirmed that the guest (AVR) was included inside the host (Mβ-CD) cavity.

In-vitro dissolution and microbial inhibition studies on anticancer drug etoposide with β-cyclodextrin.

In this article, we have reported the inclusion complex behaviors and their pharmaceutical application of anticancer drug property of Etoposide with β-cyclodextrin. The inclusion complex is used to improve the poor aqueous solubility of the anticancer drug Etoposide. The aqueous solubility and in-vitro dissolution studies support to the anticancer drug Etoposide with β-cyclodextrin complex is significantly improves the aqueous solubility.