[Etiologic and pathogenetic aspects of the demyelinating process in multiple sclerosis].

In our opinion there is no specific germ for multiple sclerosis. The pathogenic process is developed after a clinically "silent" period and results in a demyelinization process. Partially genetical aspects have to take into account for certain disease processes.

[Progress of research in the diagnosis of multiple sclerosis by study of the cerebrospinal fluid].

There are neither specific cell investigations nor immunological tests for the diagnosis of MS. Various immunological alterations occur in the course of the disease, but none is unique to MS. Accurate diagnosis remains confined to the clinical field.

[Diagnostic assessment of cerebrospinal fluid protein in brain and spinal tumors].

The cerebrospinal fluid of 69 patients with tumors of the brain and the spine was examined for total protein content, IgG concentration, IgG total protein quotient, and electrophoretic protein pattern. There is no specific finding in the case of the central nervous system. At best characteristic constellations may be established.

[Clinical and pathophysiologic aspects of viral infections of the CNS].

The available defensive mechanisms are generally sufficient to protect the central nervous system (CNS) against the penetration of infectious particles. The blood-brain-barrier plays a decisive role in this process. The present paper represents the most important circumstances realizing that: 1.

Research approaches on the diagnosis of multiple sclerosis by CSF examination.

The diagnostic value of CSF oligoclonal IgG bands, intrathecal IgG synthesis, cytology and markers of myelin breakdown in the cerebro-spinal fluid were evaluated in multiple sclerosis. None of the various immunological alterations were unique to MS. The diagnosis depends therefore mainly on course and clinical symptoms, but can be supported by CSF analysis.

[Incidence and distribution of multiple sclerosis in Halle District].

An epidemiological study of multiple sclerosis (MS) in the district of Halle, Halle-Neustadt and the area near the river Saale was carried out. We found 178 patients with a definite diagnosis in a total population of 396,529, corresponding to a prevalence of 44.9/100,000.