Publications by authors named "Kuo-Wei Lai"

Susceptibility tensor imaging (STI) is an emerging magnetic resonance imaging technique that characterizes the anisotropic tissue magnetic susceptibility with a second-order tensor model. STI has the potential to provide information for both the reconstruction of white matter fiber pathways and detection of myelin changes in the brain at mm resolution or less, which would be of great value for understanding brain structure and function in healthy and diseased brain. However, the application of STI in vivo has been hindered by its cumbersome and time-consuming acquisition requirement of measuring susceptibility induced MR phase changes at multiple head orientations.

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MR images of the effective relaxation rate R* and magnetic susceptibility χ derived from multi-echo T*-weighted (T*w) MRI can provide insight into iron and myelin distributions in the brain, with the potential of providing biomarkers for neurological disorders. Quantification of R* and χ at submillimeter resolution in the cortex in vivo has been difficult because of challenges such as head motion, limited signal to noise ratio, long scan time, and motion related magnetic field fluctuations. This work aimed to improve the robustness for quantifying intracortical R* and χ and analyze the effects from motion, spatial resolution, and cortical orientation.

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Quantitative Susceptibility Mapping (QSM) estimates tissue magnetic susceptibility distributions from Magnetic Resonance (MR) phase measurements by solving an ill-posed dipole inversion problem. Conventional single orientation QSM methods usually employ regularization strategies to stabilize such inversion, but may suffer from streaking artifacts or over-smoothing. Multiple orientation QSM such as calculation of susceptibility through multiple orientation sampling (COSMOS) can give well-conditioned inversion and an artifact free solution but has expensive acquisition costs.

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We propose and demonstrate a novel device structure of resonant cavity-enhanced photodetector (RCE-PD). The new RCE-PD structure consists of a bottom distributed Bragg reflector (DBR), a cavity with InGaAs multiple quantum wells (MQWs) for light absorption and a top mirror of sub-wavelength grating. By changing the fill factor of the 2-D grating, the effective cavity length of RCE-PDs can be varied so the resonant wavelength can be selected post growth.

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