PredCRP: predicting and analysing the regulatory roles of CRP from its binding sites in Escherichia coli.

Cyclic AMP receptor protein (CRP), a global regulator in Escherichia coli, regulates more than 180 genes via two roles: activation and repression. Few methods are available for predicting the regulatory roles from the binding sites of transcription factors. This work proposes an accurate method PredCRP to derive an optimised model (named PredCRP-model) and a set of four interpretable rules (named PredCRP-ruleset) for predicting and analysing the regulatory roles of CRP from sequences of CRP-binding sites.

Robustness and adaptation reveal plausible cell cycle controlling subnetwork in Saccharomyces cerevisiae.

Biological systems are often organized spatially and temporally by multi-scale functional subsystems (modules). A specific subcellular process often corresponds to a subsystem composed of some of these interconnected modules. Accurate identification of system-level modularity organization from the large scale networks can provide valuable information on subsystem models of subcellular processes or physiological phenomena.

Accurate and fast computational method for identifying protein function using protein-protein interaction data.

A novel quantity called functional correlation was proposed to evaluate functional closeness of a protein with its neighbors in a PPI network. Each unclassified protein was assigned a functional probability distribution which specified the likelihood of an unclassified protein belonged to a specific function group. The functional probability distribution for all unclassified proteins were adjusted iteratively until the functional correlation reached optimum.

Evaluation of antinociceptive, anti-inflammatory and antipyretic effects of Strobilanthes cusia leaf extract in male mice and rats.

The leaf of Strobilanthes cusia (Acanthaceae), popularly known as Da-Ching-Yeh, has been commonly used in traditional Chinese medicine. It is used for influenza, epidemic cerebrospinal meningitis, encephalitis B, viral pneumonia and mumps. It is also used to treat sore throat, aphthae and inflammatory diseases with redness of skin, etc.