Synopsis of recent research by authors named "Kuo-Chi Cheng"
- Kuo-Chi Cheng's research primarily focuses on the development of therapies targeting the Hepatitis C virus (HCV), particularly through the design of potent inhibitors of the NS3 serine protease, a crucial enzyme for viral replication.
- His studies showcase extensive structure-activity relationship (SAR) investigations that led to the discovery of multiple novel inhibitors with improved potency and pharmacokinetic profiles, including irreversible inhibitors and a second-generation protease inhibitor, narlaprevir.
- Additionally, Cheng has conducted research to assess the economic costs related to dialysis treatments in Taiwan, highlighting the burden of out-of-pocket expenses and productivity losses in patients receiving haemodialysis and peritoneal dialysis.
