Investigation of U.S. landfill GHG reporting program methane emission models.

As part of its commitment to the United Nations Framework Convention on Climate Change, the U.S. annually develops a national estimate of methane emissions from municipal solid waste (MSW) landfills by aggregating activity data from each facility.

A versatile dilution-treatment-detection microfluidic chip platform for rapid In vitro lung cancer drug combination sensitivity evaluation.

Combination drug therapy represents an effective strategy for treating certain drug-resistant and intractable cancer cases. However, determining the optimal combination of drugs and dosages is challenging due to clonal diversity in patients' tumors and the lack of rapid drug sensitivity evaluation methods. Microfluidic technology offers promising solutions to this issue.

Impacts of free nitrous acid on stabilizing food waste and sewage sludge for anaerobic digestion.

This work investigated the effectiveness of free nitrous acid (FNA) in enhancing organic waste solubilization to improve biogas production in anaerobic digestion (AD). The results indicated that FNA pretreatment can enhance soluble organic content and control HS odor in tested organic wastes, including food waste, sewage sludge, and their combination. However, a significant decrease (>50 %) in FNA concentration was found in the reactors, possibly due to denitrifier-driven NO consumption.

Identification of potential immune-related hub genes in Parkinson's disease based on machine learning and development and validation of a diagnostic classification model.

Background: Parkinson's disease is the second most common neurodegenerative disease in the world. However, current diagnostic methods are still limited, and available treatments can only mitigate the symptoms of the disease, not reverse it at the root. The immune function has been identified as playing a role in PD, but the exact mechanism is unknown.

Sorption and diffusion of per-polyfluoroalkyl substances (PFAS) in high-density polyethylene geomembranes.

The objective of this study is to investigate the fate and transport of per-polyfluoroalkyl substances (PFAS) through a high-density polyethylene (HDPE) geomembrane (GM) that is commonly used in landfill composite liner systems. Tests were conducted to measure the sorption and diffusion of per-polyfluoroalkyl substances (PFAS) with varying number of carbons in chain and functional groups on HDPE GM. Perfluoroalkyl carboxyl acids (PFCAs), perfluoroalkyl sulphonic acids (PFSAs), alkyl-sulfonamidoacetic acids (FOSAAs), fluorotelomer sulfonic acids (FtSAs), alkane sulfonamides (FOSA) and ether carboxylic acids (Gen X) were investigated in this study.

Identifying Vital Nodes in Hypergraphs Based on Von Neumann Entropy.

Hypergraphs have become an accurate and natural expression of high-order coupling relationships in complex systems. However, applying high-order information from networks to vital node identification tasks still poses significant challenges. This paper proposes a von Neumann entropy-based hypergraph vital node identification method (HVC) that integrates high-order information as well as its optimized version (semi-SAVC).

Hydraulic conductivity of GCL overlap permeated with saline solutions.

Hydraulic conductivity of the overlap region of two needle-punched sodium bentonite (Na-B) geosynthetic clay liners (GCLs) permeated with CaCl solutions under confining stresses of 20, 100, 250, and 500 kPa were evaluated. One of the GCLs consisted of a uniform layer of Na-B encapsulated between a nonwoven (NW) and a woven (W) geotextile, and the other one consisted of NW geotextiles on both sides. Supplemental bentonite was placed within the overlap region.

Identification of diagnostic signatures associated with immune infiltration in Alzheimer's disease by integrating bioinformatic analysis and machine-learning strategies.

Objective: As a chronic neurodegenerative disorder, Alzheimer's disease (AD) is the most common form of progressive dementia. The purpose of this study was to identify diagnostic signatures of AD and the effect of immune cell infiltration in this pathology.

Methods: The expression profiles of GSE109887, GSE122063, GSE28146, and GSE1297 were downloaded from the Gene Expression Omnibus (GEO) database to obtain differentially expressed genes (DEGs) between AD and control brain samples.

Identification of circulating immune landscape in ischemic stroke based on bioinformatics methods.

Ischemic stroke (IS) is a high-incidence disease that seriously threatens human life and health. Neuroinflammation and immune responses are key players in the pathophysiological processes of IS. However, the underlying immune mechanisms are not fully understood.

Dissecting and analyzing the Subclonal Mutations Associated with Poor Prognosis in Diffuse Glioma.

The prognostic and therapeutic implications in diffuse gliomas are still challenging. In this study, we first performed an integrative framework to infer the clonal status of mutations in glioblastomas (GBMs) and low-grade gliomas (LGGs) by using exome sequencing data from TCGA and observed both clonal and subclonal mutations for most mutant genes. Based on the clonal status of a given gene, we systematically investigated its prognostic value in GBM and LGG, respectively.

Long Non-coding RNA RMST Worsens Ischemic Stroke via MicroRNA-221-3p/PIK3R1/TGF-β Signaling Pathway.

Much efforts have been made to probe the mechanism underlying ischemic stroke (IS). This study was proposed to uncover the role of long non-coding RNA rhabdomyosarcoma 2 related transcript (RMST) in IS through microRNA-221-3p (miR-221-3p)/phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1)/transforming growth factor-β (TGF-β) axis. Neurological behavioral function, pathological changes in brain tissue, oxidative stress, and inflammation responses in middle cerebral artery occlusion (MCAO) mice were tested.

Effect of incineration ash leachates on the hydraulic conductivity of bentonite-polymer composite geosynthetic clay liners.

A study was conducted to evaluate the hydraulic conductivity (k) of six bentonite-polymer composite (BPC) geosynthetic clay liners (GCLs) using five synthetic municipal solid waste incineration ash (IA) leachates with ionic strength (I) ranging from 174 to1978 mM. The BPC GCLs contained a dry blend of bentonite and proprietary polymers and had polymer loading ranging from 0.5 to 5.

Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway.

Introduction: Cerebral ischemic injury is associated with long-term disability. Dexmedetomidine (Dex) can exert neuroprotective effects on cerebral ischemic/reperfusion injury. The present study explored the mechanism of Dex in cerebral ischemic injury.

The complete mitogenome and phylogenetic analysis of Indian driftfish, (Scombriformes: Nomeidae).

The Indian driftfish () is one of the most important commercial fish species in China, Japan and India. The complete mitogenome of was determined in this study. The assembled mitogenome was 16,507 bp and consisted of 13 protein-coding genes, 22 tRNAs, two rRNAs, and a control region.

Characterization of the complete mitochondrial genome of and phylogenetic studies of Sciaenidae.

The complete mitochondrial genome of was sequenced. The full length of the mitochondrial genome was 16,501 bp, including 13 protein-coding genes (PCGs), two ribosomal RNAs, 22 transfer RNA genes, a non-coding control region (CR) and one origin of replication on the light-strand (OL). The total nucleotide composition of mitochondrial DNA was 26.

Construction of a TF-miRNA-gene feed-forward loop network predicts biomarkers and potential drugs for myasthenia gravis.

Myasthenia gravis (MG) is an autoimmune disease and the most common type of neuromuscular disease. Genes and miRNAs associated with MG have been widely studied; however, the molecular mechanisms of transcription factors (TFs) and the relationship among them remain unclear. A TF-miRNA-gene network (TMGN) of MG was constructed by extracting six regulatory pairs (TF-miRNA, miRNA-gene, TF-gene, miRNA-TF, gene-gene and miRNA-miRNA).

Xanthohumol protects neuron from cerebral ischemia injury in experimental stroke.

Treatment of antioxidants is necessary to protect ischemic stroke associated neuronal damage. Xanthohumol (XN), a natural flavonoid extracted from hops, has been reported to have potential function as an antioxidant and can be used for neuro protection. However, the role of XN in ischemic stroke remains unclear.

Construction of a long non‑coding RNA‑mediated transcription factor and gene regulatory triplet network reveals global patterns and biomarkers for ischemic stroke.

Ischemic stroke (IS) is a severe neurological disease and a major cause of death and disability throughout the world. A long non‑coding (lnc)RNA, transcription factor (TF) and gene can form a lncRNA‑mediated regulatory triplet (LncMRT), which is a functional network motif that regulates numerous aspects of human diseases. However, systematic identification and molecular characterization of LncMRTs and their roles in IS has not been carried out.

Geochemical Characteristics and Toxic Elements in Alumina Refining Wastes and Leachates from Management Facilities.

A nationwide investigation was carried out to evaluate the geochemical characteristics and environmental impacts of red mud and leachates from the major alumina plants in China. The chemical and mineralogical compositions of red mud were investigated, and major, minor, and trace elements in the leachates were analyzed. The mineral and chemical compositions of red mud vary over refining processes (i.

[Characteristic bioanalysis of skeletal muscle cells gene markers in septic patients].

Objective: To analyze the characteristics of skeletal muscle cells gene markers in septic patients by using bioinformatics.

Methods: The differential gene expression of marker microarrays (GSE13205) in skeletal muscle tissue of patients with sepsis was obtained from gene expression omnibus (GEO) database of National Center for Biotechnology Information (NCBI). Gene differential expression analysis was carried out using online GEO2R provided by NCBI.

Integrating multiple-level molecular data to infer the distinctions between glioblastoma and lower-grade glioma.

Glioblastomas (GBMs) and lower-grade gliomas (LGGs) are the most common malignant brain tumors. Despite extensive studies that have suggested that there are differences between the two in terms of clinical profile and treatment, their distinctions on a molecular level had not been systematically analyzed. Here, we investigated the distinctions between GBM and LGG based on multidimensional data, including somatic mutations, somatic copy number variants (SCNVs), gene expression, lncRNA expression and DNA methylation levels.

[Niche and interspecific associations of major nekton in northern coastal waters in Yuhuan, Taizhou, China].

Base on the data from fishery resources survey carried out in northern coastal waters in Yuhuan in November 2016 (autumn) and April 2017 (spring), we examined the niche and interspecific associations of major nekton by the methods of index of relative importance (IRI), niche breadth, niche overlap, the variance ratio (VR), X-test, association coefficient (AC), Jaccard index (JI), point correlation coefficient (Φ) and Spearman rank correlation index. The ecological niche breadth of Portunus trituberculatus was the largest, with the absolute competitive advantage. The niche breadths of the important economic species Coilia nasus and Octopus variabilis were the smallest, which was at a weak competitive position.

The long noncoding RNA MALAT-1 functions as a competing endogenous RNA to regulate MSL2 expression by sponging miR-338-3p in myasthenia gravis.

Myasthenia gravis (MG) is a cell-dependent autoimmune disease commonly associated with thymic pathology. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) has been associated with gene regulation and alternative splicing. It has shown relationship with proliferation, apoptosis, migration, and invasion.

[Niche and interspecific association of the dominant fish in the south coastal waters of Wenzhou, China].

The studies about the niche and interspecific association in China were mainly focused on the plants, birds and marine animals, and seldom on fish. Based on the fishery resources survey in spring (May) and autumn (September) in 2015, the associations among major fish species in south coastal waters of Wenzhou were investigated. The methods including niche breadth, niche overlap, variance ratio (VR), Χ-test, association coefficient (AC), percentage of co-occurrence (PC) and point correlation coefficients (Ф) were used.

Therapeutic effect of Ginkgo biloba polysaccharide in rats with focal cerebral ischemia/reperfusion (I/R) injury.

An araban type polysaccharide (GBPw) was purified from the leaves of Ginkgo biloba. The present study aimed to investigate the protective effects of GBPw on focal ischemia/reperfusion (I/R) injury in rat brain. The results of this study demonstrated that GBPw had a positive effect on the rat brain when administered 7 days before focal cerebral I/R injury.