V-doped MoS nanozymes providing reactive oxygen species and depleting glutathione for photothermally-enhanced nanocatalytic therapy.

The tumor microenvironment and multidrug resistance of tumor cells seriously impair the activity of the nanozymes. Herein, a polyethylene glycol (PEG)-modified vanadium-doped molybdenum disulfide (V-MoS@PEG) nanozymes were constructed to enhance anti-tumor activity through multi-enzymatic catalysis and photothermal effect with simultaneous reactive oxygen species replenishment and glutathione depletion. V-MoS@PEG nanosheets exerted peroxidase activity by causing molybdenum ion (Mo) to react with hydrogen peroxide to form toxic hydroxyl radicals (·OH).

Corrigendum: Tailoring mSiO-SmCo nanoplatforms for magnetic/photothermal effect-induced hyperthermia therapy.

[This corrects the article DOI: 10.3389/fbioe.2023.

Tailoring mSiO-SmCo nanoplatforms for magnetic/photothermal effect-induced hyperthermia therapy.

Hyperthermia therapy is a hotspot because of its minimally invasive treatment process and strong targeting effect. Herein, a synergistic magnetic and photothermal therapeutic nanoplatform is rationally constructed. The well-dispersive mSiO-SmCo nanoparticles (NPs) were synthesized through a one-step procedure with the regulated theoretical molar ratio of Sm/Co among 1:1, 1:2, and 1:4 for controlling the dispersion and magnetism properties of SmCo NPs growth in the pore structure of mesoporous SiO (mSiO), where mSiO with diverse porous structures and high specific surface areas serving for locating the permanent magnetic SmCo NPs.

The clinical significance and mechanism of microRNA-22-3p targeting TP53 in lung adenocarcinoma.

Background: At present, studies on MircoRNA-22-3p (miR-22-3p) in lung adenocarcinoma use a single method, lack multi-center validation and multi-method validation, and there is no big data concept to predict and validate target genes.

Objective: To investigate the expression, potential targets and clinicopathological significance of miR-22-3p in lung adenocarcinoma (LUAD) tissues.

Methods: LUAD formalin-fixed paraffin-embedded (FFPE) tumors and adjacent normal lung tissues were collected for real-time quantitative polymerase chain reaction (RT-qPCR).