ZnO-Nafion assisted optical fiber dual-SPR biosensor for simultaneous detection of urea and uric acid concentrations.

A novel dual-parameter optical fiber biosensor based on surface plasmon resonance (SPR) for simultaneous measurement of urea and uric acid concentrations is proposed in this paper. Based on the principle of positive and negative electric combination, ZnO nanoparticles is selected as the matrix for immobilizing urease and uricase with selective recognition ability, which can also be used as a sensitizing material to increase the refractive index detection sensitivity of SPR by 22%. Then, Nafion ion exchange membrane was introduced to wrap the urea sensing area to avoid crosstalk caused by the overlap of adjacent sensing areas.

Targeting mitochondria by lipid-selenium conjugate drug results in malate/fumarate exhaustion and induces mitophagy-mediated necroptosis suppression.

Atherosclerosis (AS) is a chronic vascular disease primarily affecting large and medium-sized arteries and involves various complex pathological mechanisms and factors. Previous studies have demonstrated a close association between atherosclerosis and inflammatory damage, metabolic disorders, and gut microbiota. It is also closely linked to several cellular processes, such as endothelial cell pyroptosis, ferroptosis, mitophagy, mitochondrial dynamics, and mitochondrial biogenesis.

Detection and Quantification of 5moU RNA Modification from Direct RNA Sequencing Data.

Background: Chemically modified therapeutic mRNAs have gained momentum recently. In addition to commonly used modifications (., pseudouridine), 5moU is considered a promising substitution for uridine in therapeutic mRNAs.

Spatiotemporal joint analysis of PM and Ozone in California with INLA approach.

The substantial threat of concurrent air pollutants to public health is increasingly severe under climate change. To identify the common drivers and extent of spatiotemporal similarity of PM and ozone (O), this paper proposed a log Gaussian-Gumbel Bayesian hierarchical model allowing for sharing a stochastic partial differential equation and autoregressive model of order one (SPDE-AR(1)) spatiotemporal interaction structure. The proposed model, implemented by the approach of integrated nested Laplace approximation (INLA), outperforms in terms of estimation accuracy and prediction capacity for its increased parsimony and reduced uncertainty, especially for the shared O sub-model.

Ultrathin carbon film as ultrafast rechargeable cathode for hybrid sodium dual-ion capacitor.

The development of electrochemical energy storage devices has a decisive impact on clean renewable energy. Herein, novel ultrafast rechargeable hybrid sodium dual-ion capacitors (HSDICs) were designed by using ultrathin carbon film (UCF) as the cathode material. The UCF is synthesized by a simple low temperature catalytic route followed by an acid leaching process.

Research progress on intestinal microbiota regulating cognitive function through the gut-brain axis.

The intestinal microbiota community is a fundamental component of the human body and plays a significant regulatory role in maintaining overall health and in the management disease states.The intestinal microbiota-gut-brain axis represents a vital connection in the cognitive regulation of the central nervous system by the intestinal microbiota.The impact of intestinal microbiota on cognitive function is hypothesized to manifest through both the nervous system and circulatory system.