Publications by authors named "Kunxu Niu"
Bazi Bushen mitigates age-related muscular atrophy by alleviating cellular senescence of skeletal muscle.
J Tradit Complement Med
September 2024
Background And Aim: Muscular atrophy is one of the most common age-related conditions characterized by the deterioration of skeletal muscle structures and impaired functions. It is associated with cellular senescence and chronic inflammation, which impair the function of muscle stem cells. Bazi Bushen (BZBS) is a patent compound Chinese medicine that has been shown to have anti-aging effects in various animal models.
View Article and Find Full Text PDFBazi Bushen (BZBS), a traditional Chinese medicine (TCM), has demonstrated therapeutic efficacy in testicular dysfunction within D-galactose and NaNO mouse models. This study aimed to ascertain if BZBS could also mitigate the decline in testicular function associated with natural aging. Therefore, male aged mice were employed to evaluate the preventive effects of BZBS on male reproductive aging.
View Article and Find Full Text PDFArticle Synopsis
- Chronic inflammation and metabolic dysfunction contribute to aging and related diseases, with Bazi Bushen (BZBS) showing potential in delaying biological aging through modulating DNA methylation.
- In the study, researchers created an Energy Expenditure Aging Index (EEAI) to assess biological age and analyzed the effects of BZBS on aging mice's metabolic and inflammatory profiles over 8 months.
- Results indicated that BZBS improved energy expenditure, reduced fat accumulation, enhanced lipid metabolism, and inhibited inflammation-related pathways, thus demonstrating its promising role in mitigating age-related metabolic issues.
Purpose: The senescence-accelerated prone mouse 8 (SAMP8) is a widely used model for accelerating aging, especially in central aging. Mounting evidence indicates that the microbiota-gut-brain axis may be involved in the pathogenesis and progression of central aging-related diseases. This study aims to investigate whether Bazi Bushen capsule (BZBS) attenuates the deterioration of the intestinal function in the central aging animal model.
View Article and Find Full Text PDFBazi Bushen (BZBS), a traditional Chinese medicine, has been proven effective in the treatment of age-related disease in mouse models. However, whether its therapeutic effects are due to antiaging mechanism has not yet been explored. In the present study, we investigated the antiaging effects of BZBS in naturally aging mice by using behavioral tests, liver DNA methylome sequencing, methylation age estimation, and frailty index assessment.
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