Rotate or Wrap? Interactive Visualisations of Cyclical Data on Cylindrical or Toroidal Topologies.

In this paper, we report on a study of visual representations for cyclical data and the effect of interactively wrapping a bar chart 'around its boundaries'. Compared to linear bar chart, polar (or radial) visualisations have the advantage that cyclical data can be presented continuously without mentally bridging the visual 'cut' across the left-and-right boundaries. To investigate this hypothesis and to assess the effect the cut has on analysis performance, this paper presents results from a crowdsourced, controlled experiment with 72 participants comparing new continuous panning technique to linear bar charts (interactive wrapping).

MicroRNA-449 targets histone deacetylase 1 to regulate the proliferation, invasion, and apoptosis of synovial fibroblasts in rheumatoid arthritis.

Background: Rheumatoid arthritis (RA) is a chronic joint disease. The study aimed to explore the effects of microRNA (miR)-449 and histone deacetylase 1 (HDAC1) on the proliferation, invasion, and apoptosis of synovial fibroblasts in rheumatoid arthritis.

Methods: Synovial tissue was collected from 20 patients with RA and 20 patients with osteoarthritis (OA) who underwent joint replacement surgery.

Tumor necrosis factor receptor-associated factor 6 (TRAF6) inhibition modulates bone loss and matrix metalloproteinase expression levels in collagen-induced rheumatoid arthritis rat.

Background: Rheumatoid arthritis (RA) is a main characterized by persistent synovitis, systemic inflammation, and autoantibodies. Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an E3 ubiquitin ligase and is a crucial cytoplasm signal adaptor that can regulate critical biological processes. This research aims to explore the function of TRAF6 on bone loss and matrix metalloproteinase (MMP) expression in collagen-induced RA rats.