Torsemide in the Management of Essential Hypertension.

Torsemide, a loop diuretic, is increasingly recognized for its role in managing essential hypertension. Its mechanism of action involves inhibiting the reabsorption of sodium and chloride ions in the ascending loop of Henle in the kidneys. By doing so, torsemide promotes diuresis, which refers to increased urine production, and subsequently lowers blood pressure.

Analysis of intracardiac electrocardiogram during ill-sustained tachycardia - Door to a successful troubleshooting of 'unnecessary' defibrillator discharge.

A 50-year-old gentleman with old anterior wall myocardial infarction with implantable cardioverter defibrillator (ICD, Abbott Medical, Fortify ST VR 1235-40) presented with recurrent appropriate ICD shock. The ICD stored EGM indicated a possibility of supraventricular tachycardia (SVT) rather than ventricular tachycardia (VT) when the morphology match was found high. Bundle brunch re-entry (BBR) VT was another differential.

Rashba effect on finite temperature magnetotransport in a dissipative quantum dot transistor with electronic and polaronic interactions.

The Rashba spin-orbit coupling induced quantum transport through a quantum dot embedded in a two-arm quantum loop of a quantum dot transistor is studied at finite temperature in the presence of electron-phonon and Hubbard interactions, an external magnetic field and quantum dissipation. The Anderson-Holstein-Caldeira-Leggett-Rashba model is used to describe the system and several unitary transformations are employed to decouple some of the interactions and the transport properties are calculated using the Keldysh technique. It is shown that the Rashba coupling alone separates the spin-up and spin-down currents causing zero-field spin-polarization.

Parenteral pentazocine and diabetes mellitus: a double whammy for cutaneous complication.

Pentazocine, a non-narcotic analgesic, though has no addictive potential but abused frequently via parenteral route for its psychological dependence. It causes local sclerosis resulting in non-healing ulcer at injection sites. Diabetes mellitus suppress host immunity, making them vulnerable to various bacterial skin and soft tissue infection among which mkethicillin resistant staphylococcus aureus (MRSA) infection are predominant.

Haemorrhagic pericardial effusion in type I Gaucher's disease.

Gaucher's disease is a rare lysosomal storage disorder. Excess accumulation of glucosylceramide predominantly occurs in abdominal viscera. Cardiac involvement is rare, though they generally represent as restrictive cardiomyopathy and pericarditis.

Unravelling the Gordian knot: diagnostic dilemma in an HIV-positive patient with neurological involvement.

We report a case of a 40-year-old seropositive-HIV patient with a CD4 count of 120 who presented with fever, severe headache and neck stiffness. Suspecting a case of tubercular meningitis (TBM; as tuberculosis is the commonest opportunistic infection in HIV/AIDS patients in India), a lumbar puncture was performed and a cerebrospinal fluid study revealed TBM. The patient was started on combination antitubercular drug therapy from directly observed treatment, short course (DOTS) (Cat 1 regimen) along with pyridoxine 40 mg/day and adjunctive corticosteroid therapy.

Incidence and risk factors of immune reconstitution inflammatory syndrome in HIV-TB coinfected patients.

Unlabelled: Tuberculosis is one of the leading causes of development of Immune reconstitution inflammatory syndrome (IRIS) in HIV patients receiving antiretroviral therapy (ART).

Objective: To determine the incidence of IRIS in HIV-TB coinfected patients, and to find out the possible risk factors associated with IRIS.

Materials And Methods: Study commenced with 96 patients adhered to standard antitubercular therapy (ATT) and ART without defaulting, and followed up for six months.

Assessment of efficacy of pamidronate in undifferentiated spondyloarthropathy (uSpA): a placebo control trial in a tertiary level center.

Undifferentiated spondyloarthropathy (uSpA) is a nonspecific form of spondyloarthropathy where nonsteroidal anti-inflammatory drugs (NSAIDs) and disease-modifying anti-rheumatic drugs are still mainstay of treatment. We evaluated the efficacy and adverse effect profile of pamidronate, in uSpA patients refractory to NSAIDs therapy. A case series of 87 patients fulfilling the modified Amor criteria for the diagnosis of uSpA, having active disease even after 3-month continuous therapy with two NSAIDs, were selected.

Serum creatine phosphokinase: a probable marker of severity in organophosphorus poisoning.

Organophosphorus (OP), the commonest agent for poisoning in India due to its easy availability, acts by inhibiting acetylcholinesterase at muscarinic and nicotinic receptors. Erythrocyte cholinesterase (EchE) and plasma cholinesterase (PchE) are reduced in OP poisoning, but their estimation is costly and not regularly performed. There are emerging options for new cheaper biochemical markers in relation to OP poisoning.