[Mechanism of action of Nizhne-Ivkinskaya 2K sulfate-calcium mineral water in combined treatment of acid-dependent gastrointestinal diseases].

Aim: To study efficacy of drinking mineral water (MW) nizhne-ivkinskaya 2K in combined sanatorium treatment of gastrointestinal acid-dependent diseases (ADD) and the role of endogenic modulators of M-cholinoreactivity in pathogenesis of ADD.

Material And Methods: General condition of the patients, gastric pH and peristalsis (computer system Gastrolog-M), gastric and gall bladder motility (Aloka SSD 1100), hepatic function (by bilirubin and AST and ALT activity), lipid spectrum (including LDLP and HDLP) and M-cholinomodulating activity of the blood serum (by biomethod) were examined in 134 subjects: 20 healthy subjects and 114 patients with ADD.

Results: In ADD, gastric juice acidity is high, gastric and gall bladder motility is low, total cholesterol and LDLP cholesterol are elevated, M-cholinoblocking activity of the blood serum is reduced 10-fold.

Influence of lysophosphatidylcholine, phosphatidylcholine, and hen egg yolk on contractile effects of acetylcholine on smooth muscles of rat stomach.

Experiments on smooth muscles of rat stomach showed that lysophosphatidylcholine in concentrations of 10(-8) and 10(-7) g/ml does not modulate the tonotropic effect of acetylcholine (10(-6) g/ml), in a concentration of 10(-6) g/ml potentiated this effect (similarly to phosphatidylcholine, 10(-6) g/ml), and reduced it in concentrations of 10(-5)-10(-4) g/ml (similarly to hen egg yolk in dilutions of 1:500, 1:100, and 1:500). These data indicate that lysophosphatidylcholine modifies signal transduction from the receptor to G protein.