This study explored how 8-methoxypsoralen (8-MOP) impacts liver damage caused by acetaminophen (APAP) in mice, revealing that 8-MOP reduces liver injury and inflammation indicators.
Treatment with varying doses of 8-MOP showed a dose-dependent reduction in hepatotoxicity without affecting the liver negatively at the highest dose.
The research indicates that 8-MOP works by inhibiting the Cyp2e1 enzyme, which decreases the formation of a toxic metabolite from APAP, thus providing a protective effect against liver damage.
Herbaspirillum sp. WT00C is a tea-plant-specific endophytic bacterium. A genomic survey revealed an intact pathway for selenocompound metabolism in the genome of this bacterium.