Publications by authors named "Kunmei Yang"

Article Synopsis
  • Serum amyloid A (SAA) is an important protein that plays a role in the innate immune response to infections, including Marek's disease virus (MDV), which activates SAA during its invasion.
  • Researchers found that SAA expression increased significantly during MDV infection and that it can inhibit MDV replication through its activation of specific immune signaling pathways.
  • The study identified that SAA enhances Toll-Like Receptor 2/4 (TLR2/4) pathways, promoting the expression of interferons (IFNs) and interferon-stimulated genes (ISGs), revealing a new mechanism for how SAA contributes to the immune response against MDV.
View Article and Find Full Text PDF

Zinc finger antiviral proteins (ZAP) can significantly inhibit the replication of avian leukosis virus subgroup J (ALV-J), but the traditional method of ZAP administration is by injection, which can easily cause stress effects in chickens. In this work, we established a sodium alginate/atractylodis macrocephalae system for the encapsulation of CCCH-type zinc finger antiviral protein (CCCH-ZAP). Because of the high cost of ZAP, we first chose bovine serum albumin (BSA) as a model protein to investigate the encapsulation performance.

View Article and Find Full Text PDF
Article Synopsis
  • Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus that causes tumors in chickens.
  • Recent research has revealed that ALV-J uses host molecules like MIF to enhance its infection process, although the exact molecular mechanisms are not fully understood.
  • The study shows that proteins p10 and p27 from ALV-J's Gag protein interact with MIF, promoting ALV-J infection by aiding its internalization and replication, which could lead to new methods for controlling such viruses.
View Article and Find Full Text PDF

The CCCH-type zinc finger antiviral protein (ZAP) can recognize and induce the degradation of mRNAs and proteins of certain viruses, as well as exerting its antiviral activity by activating T cells. However, the mechanism of ZAP that mediates T cell activation during virus infection remains unclear. Here, we found a potential function of ZAP that relieves immunosuppression of T cell induced by avian leukosis virus subgroup J (ALV-J) via a novel signaling pathway that involves norbin-like protein (NLP), protein kinase C delta (PKC-δ), and nuclear factor of activated T cell (NFAT).

View Article and Find Full Text PDF