Publications by authors named "Kunmei Yang"
Article Synopsis
- Serum amyloid A (SAA) is an important protein that plays a role in the innate immune response to infections, including Marek's disease virus (MDV), which activates SAA during its invasion.
- Researchers found that SAA expression increased significantly during MDV infection and that it can inhibit MDV replication through its activation of specific immune signaling pathways.
- The study identified that SAA enhances Toll-Like Receptor 2/4 (TLR2/4) pathways, promoting the expression of interferons (IFNs) and interferon-stimulated genes (ISGs), revealing a new mechanism for how SAA contributes to the immune response against MDV.
Zinc finger antiviral proteins (ZAP) can significantly inhibit the replication of avian leukosis virus subgroup J (ALV-J), but the traditional method of ZAP administration is by injection, which can easily cause stress effects in chickens. In this work, we established a sodium alginate/atractylodis macrocephalae system for the encapsulation of CCCH-type zinc finger antiviral protein (CCCH-ZAP). Because of the high cost of ZAP, we first chose bovine serum albumin (BSA) as a model protein to investigate the encapsulation performance.
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- Avian leukosis virus subgroup J (ALV-J) is an oncogenic retrovirus that causes tumors in chickens.
- Recent research has revealed that ALV-J uses host molecules like MIF to enhance its infection process, although the exact molecular mechanisms are not fully understood.
- The study shows that proteins p10 and p27 from ALV-J's Gag protein interact with MIF, promoting ALV-J infection by aiding its internalization and replication, which could lead to new methods for controlling such viruses.
The CCCH-type zinc finger antiviral protein (ZAP) can recognize and induce the degradation of mRNAs and proteins of certain viruses, as well as exerting its antiviral activity by activating T cells. However, the mechanism of ZAP that mediates T cell activation during virus infection remains unclear. Here, we found a potential function of ZAP that relieves immunosuppression of T cell induced by avian leukosis virus subgroup J (ALV-J) via a novel signaling pathway that involves norbin-like protein (NLP), protein kinase C delta (PKC-δ), and nuclear factor of activated T cell (NFAT).
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