Publications by authors named "Kunlong Hu"
Article Synopsis
- PARL is a rhomboid membrane protein essential for mitochondrial function and plays a significant role in oocyte maturation, though its specific effects are not well understood.
- Inhibiting PARL expression resulted in reduced polar body extrusion and abnormal embryo development, along with negative impacts on mitochondrial activity and increased oxidative stress in porcine oocytes.
- PARL deficiency also altered the expression of key genes related to mitochondrial function and DNA integrity, emphasizing its critical role in the maturation process of oocytes.
METTL3-mediated N6-methyladenosine (m6A) modification is critical for gametogenesis and early embryonic development. However, the function of METTL3-mediated m6A modification in the early development of somatic nuclear transfer embryos (SCNT) remains unclear. Here, we found that METTL3 mRNA and protein levels exhibit dynamic changes during the early development of porcine SCNT embryos.
View Article and Find Full Text PDFCircular RNA (circRNA) is abundantly expressed in preimplantation embryos and embryonic stem cells in mice and humans. However, its function and mechanism in early development of mammalian embryos remain unclear. Here, we showed that circHIRA mediated miR-196b-5p to regulate porcine early embryonic development.
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