Publications by authors named "Kunlin Xiao"
Article Synopsis
- - Osteoarthritis (OA) is a common, age-related condition where cartilage breaks down, leading to inflammation and bone degeneration, with the Indian hedgehog (IHH) signaling pathway playing a crucial role in cartilage health.
- - A study shows that in OA patients, IHH levels increase while the levels of miR-199a-5p, which regulates IHH, decrease, indicating a possible link between these molecules and cartilage damage.
- - In animal models, injecting a synthetic version of miR-199a-5p improved OA symptoms by preventing cartilage destruction and inflammation, suggesting it could be a promising treatment for OA.
Background: T cell immunoglobulin and ITIM domain (TIGIT) is a recently identified immunosuppressive receptor. The expression levels of TIGIT affect the prognosis of patients with solid tumors. To fully comprehend the role of TIGIT on the prognosis of patients with solid tumors, we conducted a meta-analysis.
View Article and Find Full Text PDFOsteoarthritis (OA) is a progressively degenerative disease of joints. culture of chondrocytes results in dedifferentiation, which is characterized by the development of fibroblast phenotypes, reduced ability to produce cartilage extracellular matrix (ECM) and increase the expression of molecular markers Col1a1, Col10a1 and Runx2. Redifferentiation of chondrocytes is indicated by increased expression of the molecular markers Col2a1, Aggrecan and Sox9.
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