Insights from Dysregulated mRNA Expression Profile of -Cells in Response to Proinflammatory Cytokines.

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease that is characterized by autoimmunity and its mediated -cell damage. Chronic exposure of -cells to proinflammatory cytokines is known to regulate the expression of many genes, subsequently resulting in the impairment of some signaling pathways involved with insulin production and secretion and/or -cell apoptosis. In our study, RNA sequencing technology was applied to identify differentially expressed mRNAs in MIN6 cells treated with a mix of cytokines, including IL-1, TNF-, and IFN-.

Successful eight-year survival of unresectable lung adenocarcinoma with bronchial artery infusion chemotherapy: A case report.

A case report of eight year complete remission post bronchial artery infusion (BAI) chemotherapy (Pimetrazine and cisplatin) for unresectable lung adenocarcinoma.

The crucial roles of guest water in a biocompatible coordination network in the catalytic ring-opening polymerization of cyclic esters: a new mechanistic perspective.

The ring-opening polymerization (ROP) of cyclic esters/carbonates is a crucial approach for the synthesis of biocompatible and biodegradable polyesters. Even though numerous efficient ROP catalysts have been well established, their toxicity heavily limits the biomedical applications of polyester products. To solve the toxicity issues relating to ROP catalysts, we report herein a biocompatible coordination network, CZU-1, consisting of Zn(μ-O)(COO) secondary building units (SBUs), biomedicine-relevant organic linkers and guest water, which demonstrates high potential for use in the catalytic ROP synthesis of biomedicine-applicable polyesters.

Inserting Amide into NOTT-101 to Sharply Enhance Volumetric and Gravimetric Methane Storage Working Capacity.

Amide-functionalized exhibits high volumetric and gravimetric CH working capacities of 190 cm cm and 298 cm g (from 5.8 to 65 bar), higher than that of the similar NJU-Bai43 (187 cm cm and 292 cm g). This finding indicates that nitrogen-functionalized aromatic ring may not always play a positive role in amide-MOF for CH storage.

Glycosylation and Activities of Natural Products.

Natural products are widely found in nature, their number and variety are numerous, the structures are complex and diverse. These natural products have many physiological and pharmacological activities. Glycosylation can increase the diversity of structure and function of natural product, it has become the focus of drug research and development.

Assembly of 1D, 2D and 3D lanthanum(iii) coordination polymers with perchlorinated benzenedicarboxylates: positional isomeric effect, structural transformation and ring-opening polymerisation of glycolide.

Utilizing a series of positional isomers of tetrachlorinated benzenedicarboxylic acid ligands, seven La(iii)-based coordination polymers were solvothermally synthesized and structurally characterized. Their structural dimensionalities varying from 1D double chains, to the 2D 3,4,5-connected network, to 3D 6-connected pcu topological nets are only governed by the positions of carboxyl groups on the tetrachlorinated benzene ring. A comprehensive analysis and comparison reveals that the size of the carbonyl solvent molecules (DMF, DEF, DMA, and NMP) can affect the coordination geometries around the La(iii) ions, the coordination modes of carboxylate groups, the packing arrangements, and the void volumes of the overall crystal lattices.

Crystal structure of catena-poly[[di-aqua-cadmium(II)]-μ-3,3'-(1,3-phenyl-ene)diacrylato].

In the crystal of the title polymeric complex, [Cd(C12H8O4)(H2O)2] n , the Cd(II) cation, located on a twofold rotation axis, is coordinated by two water mol-ecules and chelated by two phenyl-enediacrylate anions (mpda) in a distorted octa-hedral geometry. The mpda anions bridge the Cd(II) cations, forming helical chains propagating along the c-axis direction. The mpba anion has twofold symmetry with two benzene C atoms located on the twofold rotation axis.

Doping potassium ions in silver cyanide complexes for green luminescence.

Doping potassium ions in silver cyanide complexes leads to two heterometallic silver-potassium cyanide complexes, namely, [Me4N]2[KAg3(CN)6] (1) with a typical NaCl-type framework containing distinct ligand-unsupported argentophilic interactions, and [Ag3(H2O)3][K(CN)2]3 (2) with an unprecedented 3-D (4,4,6,6)-connected framework formed by unique [Ag3(H2O)3] clusters connecting concave-convex [K(CN)2] layers. The two complexes exhibit green luminescence, and the relationships between their structures and photoluminescence, as well as the regulating effect on the luminescence by doping of potassium ions are well investigated via density functional theory analysis.

Poly[diaqua-[μ6-4,4'-(1,4-phenyl-ene)bis-(2,6-dimethyl-pyridine-3,5-dicarboxyl-ato)]dilead(II)].

The asymmetric unit of the title Pb-based coordination polymer, [Pb2(C24H16N2O8)(H2O)2] n , consists of one Pb(II) cation, half of a 4,4'-(1,4-phenyl-ene)bis-(2,6-dimethyl-pyridine-3,5-di-carb-oxyl-ate (L (4-)) ligand and one coordinating water mol-ecule. The centers of the benzene ring of the ligand and the four-membered Pb/O/Pb/O ring are located on centers of inversion. The Pb(II) ion is coordinated in form of a distorted polyhedron by seven O atoms from four separate L (4-) ligands and by one water O atom.

Distinct chiral units from an axially prochiral ligand in a photoluminescent zinc(II)-organic complex.

The asymmetric unit of the title compound, poly[(dimethylamine-κN)[μ(3)-(E)-2,6-dimethyl-4-styrylpyridine-3,5-dicarboxylato-κ(3)O(3):O(3'):O(5)]zinc(II)], [Zn(C(17)H(13)NO(4))(C(2)H(7)N)](n), consists of one crystallographically independent distorted tetrahedral Zn(II) cation, one (E)-2,6-dimethyl-4-styrylpyridine-3,5-dicarboxylate (mspda(2-)) ligand and one coordinated dimethylamine molecule. Two S- and R-type chiral units are generated from the axially prochiral mspda(2-) ligand through C-H..

Two three-dimensional {V16Ge4}-based open frameworks stabilized by diverse types of Co(II)-amine bridges and magnetic properties.

Two novel three-dimensional (3D) extended vanadogermanate-based frameworks, [Co(pdn)(2)](3)[Co(2)(pdn)(4)][V(16)Ge(4)O(44)(OH)(2)(H(2)O)]·5H(2)O (1), [Co(2)(en)(3)][Co(en)(2)](2)[Co(en)(2)(H(2)O)][V(16)Ge(4)O(44)(OH)(2)(H(2)O)]·10.5H(2)O (2), (pdn = 1,2-propanediamine, en = ethylenediamine) have been synthesized under hydrothermal conditions via changing the organic amine. X-ray crystal structure analyses reveal that both frameworks are built of [V(16)Ge(4)O(44)(OH)(2)(H(2)O)](10-) anions and different Co-amine cations.

A binuclear zinc polymer with paddlewheel building units and intersecting helical chains based on a flexible 4-[(carboxymethyl)sulfanyl]benzoic acid ligand.

The asymmetric unit of the title compound, poly[{μ(4)-4-[(carboxylatomethyl)sulfanyl]benzoato}(N,N-dimethylformamide)zinc], [Zn(C(9)H(6)O(4)S)(C(3)H(7)NO)](n), consists of one crystallographically independent Zn(II) cation, one 4-[(carboxylatomethyl)sulfanyl]benzoate (L(2-)) ligand and one coordinated dimethylformamide (DMF) molecule. The zinc ion is coordinated by five O atoms from four separate L(2-) ligands and one DMF molecule, and the ZnO(5) unit displays a distorted square-based-pyramidal geometry. Two ZnO(5) units form a binuclear zinc-tetracarboxylate paddlewheel cluster, and these are bridged by L(2-) ligands to generate an intersecting helical chain (Zn(2+) ions as nodes), which is composed of right-handed (P) and left-handed (M) helices.

Transformation from [W6O19](2-) to [W6O22](8-) stabilized by Cu(II) complexation.

A rare [W6O22](8-) fragment has been first captured in aqueous solution of [W6O19](2-) by using a transition-metal complex and isolated as a new compound [Cu4(W6O22)(L1)2(H2O)2]·2H2O (1; L1 = 2-amino-4,6-bis(2-pyridyl)pyrimidine), indicating that [W6O19](2-) could also transform to [W6O22](8-) in aqueous solution besides the earlier proven ψ-metatungstates, [W10O32](4-), β-[(H2)W12O40](6-) and [W7O24](6-).

A 12-connected dodecanuclear copper cluster with yellow luminescence.

The 3-D 12-connected metal-organic framework [Cu(12)Br(2)(CN)(6/2)(SCH(3))(6)][Cu(SCH(3))(2)], containing dodecanuclear copper clusters, has been solvothermally synthesized and exhibits efficient yellow luminescence. The emission mechanism was studied in detail to elucidate the relationship of the luminescent properties and crystal structures, which is helpful for the design and synthesis of more efficient luminescent materials.

Lanthanide-organic cation frameworks with zeolite gismondine topology and large cavities from intersected channels templated by polyoxometalate counterions.

A family of organic-inorganic hybrid frameworks, {[Ln(H(2)O)(4)(pdc)](4)} [XMo(12)O(40)].2H(2)O (Ln = La, Ce, and Nd; X = Si and Ge; H(2)pdc = pyridine-2,6-dicarboxylate), have been prepared under hydrothermal conditions and characterized by single crystal X-ray diffraction analyses, elemental analyses, IR, and thermal gravimetric analyses. Single crystal X-ray diffraction reveals that all six compounds are isostructural, and each consists of a zeolite-like four-connected three-dimensional cationic framework {[Ln(H(2)O)(4)(pdc)](4)}(4+) and ball-shaped Keggin type [XMo(12)O(40)](4-) as templates.

A new two-dimensional supramolecule composed of mu-2,6-dimethylpyridine-3,5-dicarboxylato-kappa4O3,O3':O5,O5'-bis[chloro(1,10-phenanthroline-kappa2N,N')zinc(II)].

In the binuclear title molecule, [Zn(2)(C(9)H(7)NO(4))Cl(2)(C(12)H(8)N(2))(2)], the two metal centres are bridged by a 2,6-dimethylpyridine-3,5-dicarboxylate ligand. The binuclear unit is extended to form a two-dimensional supramolecular motif via pi-pi stacking interactions between neighbouring phenanthroline rings.

Structural diversity of silver(I) 4,6-dipyridyl-2-aminopyrimidine complexes: effect of counteranions and ligand isomerism.

Using two ligands, 4,6-bis(2-pyridyl)-2-aminopyrimidine (L1) with two N,N'-chelating sites and 4-(2-pyridyl)-6-(4-pyridyl)-2-aminopyrimidine (L2) (as the isomer of L1) containing one chelating site and one bridging unit, a series of novel Ag(I) complexes varying from zero- to two-dimensions have been prepared and their crystal structures determined via single-crystal X-ray diffraction. The two ligands are employed for the first time in coordination chemistry. The structures of compounds 1-3 are directed by the counteranions adopted in the reaction system: The reaction of L1 with AgNO3 yielded a dimer [Ag2L12](NO3)2 (1).

From layered double hydroxide to spinel nanostructures: facile synthesis and characterization of nanoplatelets and nanorods.

Mg-Al spinel (MgAl2O4) nanorods and nanoplatelets transformed from Mg-Al layered double hydroxide (Mg-Al-LDHs) were synthesized via a combined hydrothermal method and calcination route using Al(NO3).9H2O and Mg(NO3)2.6H2O as raw materials.

Controlled synthesis of nanorods/nanorings of a novel Co-Cu complex in microemulsion at room temperature.

Novel Co-Cu complex nanorods with diameters of 100-200 nm and nanorings with a ring-diameter of 80 nm were synthesized via a microemulsion method at room temperature. Using this method, the addition of Co(NH3)(3+)6 to aqueous solutions of Cu(ii) in excessive carbonate promotes the assembly of a new highly charged carbonato-copper(ii) anion, [Cu4(OH)(CO3)8]9-.