Publications by authors named "Kunliang Chen"
Article Synopsis
- The study investigates the role of orphan CpG islands (oCGIs) in the transcriptional network related to glioma, a type of brain cancer with poor prognosis.
- By integrating multi-omics data, researchers found that oCGIs and enhancers play a crucial role in regulating target genes, particularly in a specific cell cluster (C2) that exhibits high proliferation.
- The upregulation of oCGIs and enhancer-related genes in this cluster contributes to glioma cells' resistance to treatments like radiotherapy and chemotherapy, offering new insights for potential therapeutic strategies.
Purpose: To develop and validate a web-based nomogram for predicting new incident chronic kidney disease (CKD) within 4 years in a cohort undergoing routine physical examination from two health examination centers.
Methods: One center was utilized for training and internal validation of a nomogram model involving 6515 patients, while a separate center was employed for external validation with 3152 patients. Sixteen candidate predictors, including patient demographics, medical histories, physical examination, and laboratory test data, were included in this study to ascertain factors linked to new incident CKD.
The BGLF4 protein of Epstein-Barr virus (EBV) is a serine/threonine protein kinase that phosphorylates several viral and cellular substrates at cellular cyclin-dependent kinase target sites. BGLF4 is required for efficient viral DNA replication and release of mature virions. It also stimulates the transactivation activity of the immediate-early transactivator Zta (BZLF1) and suppresses the transactivation activities of BMRF1 and EBNA-2.
View Article and Find Full Text PDF