Publications by authors named "Kunjan Harit"
Background: Neutrophils play a crucial role in inflammation and in the increased thrombotic risk in myeloproliferative neoplasms (MPNs). We have investigated how neutrophil-specific expression of JAK2-V617F or CALRdel re-programs the functions of neutrophils.
Methods: Ly6G-Cre JAK2-V617F and Ly6G-Cre CALRdel mice were generated.
Article Synopsis
- * The study identifies OTUD7b, an ovarian tumor deubiquitinating enzyme, as a key player that protects DCs from TNF-induced apoptosis, which is crucial for activating CD8 T cells in response to infections.
- * OTUD7b stabilizes TRAF2 by preventing its degradation, facilitating the K63-linked polyubiquitination of RIPK1, which leads to critical immune responses like NF-κB activation and production of anti-apoptotic factors, highlighting its potential as a therapeutic target in manipulating DC functions.
In bacterial and sterile inflammation of the liver, hepatocyte apoptosis is, in contrast to necroptosis, a common feature. The molecular mechanisms preventing hepatocyte necroptosis and the potential consequences of hepatocyte necroptosis are largely unknown. Apoptosis and necroptosis are critically regulated by the ubiquitination of signaling molecules but especially the regulatory function of deubiquitinating enzymes (DUBs) is imperfectly defined.
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