Publications by authors named "Kuniyasu Kamiya"
Objectives: Studies on the relationship between serum sclerostin, a Wnt/β-catenin pathway inhibitor, and atherosclerosis have yielded inconsistent results. We aim to longitudinally investigate the relationship between serum sclerostin levels and the risk of increased arterial stiffness in Japanese community-dwelling women.
Methods: Of 1044 women aged ≥50 years whose brachial-ankle pulse wave velocity (baPWV) value was available in a baseline survey in 2011-2012, we excluded 374 whose baPWVs were ≥1800 cm/s, set as the cutoff for increased arterial stiffness, and eight with missing data.
Objective: To evaluate the relationships between baseline nutritional status, medical events (MEs), and rehabilitation outcomes in individuals undergoing inpatient rehabilitation (IR).
Design: A retrospective single center cohort study.
Setting: An IR ward.
Background: Although the effects of exercise training (ET) on sleep problem have been reported, the effects according to the components of exercise, including intensity, frequency, and time window, are unknown. Thus, in this study, we aimed to assess the effects of ET on sleep quality in community-dwelling older adults with sleep problems.
Methods: We evaluated individuals aged ≥65 years whose Pittsburgh sleep quality index was >5 points at baseline.
Objective: To assess the associations of baseline skeletal muscle mass index (SMI) with adverse events and rehabilitation outcomes in patients admitted for rehabilitation.
Design: A retrospective cohort study.
Participants: The subjects were 409 patients (mean age, 79 years; men, 167 [41%]) undergoing rehabilitation because of neurologic disease, musculoskeletal disorders, or hospital-associated deconditioning.
Background: Despite the prognostic importance of walking speed (WS) and handgrip strength (HGS) in patients with heart failure (HF), no study has reported the prognostic impact of changes in these parameters. This study aimed to examine the association between changes after discharge and the subsequent prognosis.
Methods: This study included 881 elderly patients hospitalized for HF.
Objective: Assessment of the association between anemia and recovery of physical disability in patients with functional impairment.
Design: A retrospective cohort study.
Setting: A convalescent rehabilitation ward.
Aims: Malnutrition is prevalent among patients with heart failure (HF); however, the effects of coexisting malnutrition and frailty on prognosis are unknown. This study examines the impact of malnutrition and frailty on the prognosis of patients with HF.
Methods And Results: We examined 1617 patients with HF aged 65 years or older (age: 78.
Article Synopsis
- - The study investigated the relationship between a biomarker called C-terminal agrin fragment (CAF110) and low muscle mass and strength in women aged 65 and older, using data from cross-sectional and longitudinal analyses conducted between 2011-2017.
- - Results showed that a higher CAF110 level was significantly associated with increased odds of low muscle mass, whereas the association with low muscle strength was not statistically significant, even after adjusting for age.
- - The longitudinal analysis also suggested a potential link between higher CAF110 levels and the incidence of low muscle mass over time, but the results did not reach statistical significance after controlling for other factors.
Patients with osteoporosis are prone to fragility fractures. Evidence of the effects of active forms of vitamin D on hip fracture prevention is insufficient. We examined the association between vitamin D prescription and incidence of new fractures using the data of osteoporotic patients from the nationwide health insurance claims database of Japan.
View Article and Find Full Text PDFObjective: This study aimed to assess the association between skeletal muscle mass index and falls in patients with functional impairment.
Design: This retrospective cohort study was implemented at a convalescent rehabilitation ward. Patients with no measurement of skeletal muscle mass index and bed-ridden patients were excluded from this study.
Article Synopsis
- * Among nearly 12.2 million patients, over 304,000 were diagnosed with AD, and researchers matched pairs of those who did and did not use antidementia medications.
- * Findings indicated that patients using antidementia medications had lower rates of hip and overall clinical fractures but a slight increase in radial fractures, showing potential benefits of these medications for fracture prevention in AD patients.
Background: Research regarding cardiac rehabilitation (CR) in the prognosis of heart failure (HF) patients and frailty remains lacking. Here, the effects of CR on the 2-year prognosis of HF patients were examined according to their frailty status.
Methods: This multicenter prospective cohort study enrolled patients hospitalized for HF.
Aim: To investigate the effects of high-intensity interval exercise training on microvascular endothelial function among community-dwelling older people.
Methods: We analyzed the data from a nonrandomized controlled trial. This study's participants were 48 men (aged 75 ± 5 years; exercise training group, n = 24; control group, n = 24) and 83 women (aged 75 ± 4 years; exercise training group, n = 36; control group, n = 47).
Background: Elderly patients with acute myocardial infarction (AMI) are a high-risk population for heart failure (HF), but the association between physical frailty and worsening prognosis, including HF development, has not been documented extensively.
Methods and results: As part of the FLAGSHIP study, we enrolled 524 patients aged ≥70 years hospitalized for AMI and capable of walking at discharge. Physical frailty was assessed using the FLAGSHIP frailty score.
Article Synopsis
- This study aimed to investigate the risks of fractures associated with starting various antidiabetic medications in elderly patients (65+) using a national health claims database in Japan.
- Over a period from 2012 to 2018, the research found that insulin, DPP-4 inhibitors, and alpha-glucosidase inhibitors increased hip fracture risks compared to biguanide, and insulin also raised the risk for vertebral fractures.
- The findings suggest that elderly patients starting antidiabetic drugs, particularly insulin, face higher risks of fractures, underscoring the need for careful monitoring and management of these patients.
Purpose: Early initiation of anti-osteoporosis medications (AOMs) is recommended for patients on long-term glucocorticoid (GC) therapy. This study aimed to clarify the real-world effectiveness of AOMs against incident hip and vertebral fractures in patients undergoing GC therapy using the nationwide health insurance claims database of Japan (NDBJ).
Methods: Patients aged ≥50 years who were prescribed GC (≥5 mg/day prednisolone or equivalent) for ≥90 days and who were followed up regarding AOM prescription and hip and clinical vertebral fracture incidences for the subsequent 1080 days between 2012 and 2018 were selected from NDBJ.
Effects of interval-walking training on blood pressure in community-dwelling Japanese older adults.
J Sports Med Phys Fitness
March 2023
Background: The hypotensive effects of high-intensity interval training have been reported; however, studies on older adults are few. This study aimed to examine whether interval-walking training (IWT), a home-based program of high-intensity interval training, reduces blood pressure (BP) levels when compared with a non-intervention group in community-dwelling older adults.
Methods: An intervention study was conducted with 55 men (age, 75±5 years; IWT/control groups, N.
Aims: Oral health is associated with atherosclerotic cardiovascular disease (ACVD). We previously identified the salivary microbiota characteristics of patients with ACVD. However, whether salivary microbiota is characteristic under impaired vascular endothelial function before ACVD onset remains unclear.
View Article and Find Full Text PDFObjectives: Physical frailty becomes a robust risk factor in patients with heart failure (HF) and coexistence of physical and psychological frailty is likely to be a prognostic indicator. This study aimed to analyze the prognosis of coexistence of these two factors in patients with HF.
Methods: This study was a secondary analysis of a multicenter prospective cohort study (FLAGSHIP).
Article Synopsis
- The study investigates the timing of anti-osteoporosis medication (AOM) prescriptions for patients starting long-term glucocorticoid (GC) therapy, focusing on whether physicians prescribe AOMs immediately or with delay.
- An analysis of over 186,000 patients revealed that only 39.3% of women and 28.5% of men began AOMs within 90 days of starting GC therapy; those who delayed were at a higher risk of hip and vertebral fractures.
- The findings suggest that early initiation of AOMs could significantly reduce fracture incidents, highlighting the importance of timely treatment for patients undergoing GC therapy.
Objective: The aim of the current study was to investigate the association between the skeletal muscle mass index (SMI) and the convalescent rehabilitation ward achievement index (CRWAI) in older patients with functional impairment.
Methods: We conducted a retrospective cohort study at a single rehabilitation center in Japan to include patients admitted to the convalescent rehabilitation ward because of neurological disease, motor disorder, or disuse syndrome. Patients with missing SMI data, those who died or were transferred to other hospitals due to comorbidities, those aged less than 65 years, and those hospitalized for <7 days were excluded from the study.
The prognostic effects of cardiac rehabilitation (CR) are inconsistent in recent reports on heart failure (HF). Generally, participants in previous trials were relatively young and had HF with reduced ejection fraction. Herein, we examined the effects of CR on HF prognosis using a nationwide cohort study.
View Article and Find Full Text PDFAims: Weight loss (WL) is a poor prognostic factor for patients with heart failure (HF) with reduced ejection fraction. However, its prognostic impact on patients with HF with preserved ejection fraction (HFpEF) remains unestablished. The evidence regarding the effects of obesity on the prognosis of WL is also unclear.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers collected saliva samples from 42 patients with T2DM and 42 matched controls, using advanced analysis techniques to identify microbiota characteristics.
- * Results showed significant differences in microbiota structure, with Firmicutes more prevalent in T2DM patients, leading to a strong predictive model for T2DM based on saliva analysis.