Intravitreal plasmin injection activates endogenous matrix metalloproteinase-2 in rabbit and human vitreous.

Purpose: To investigate the effect of exogenous plasmin administration on the activity of endogenous matrix metalloproteinase-2 (MMP-2) in rabbit and human vitreous.

Design: Experimental animal study and interventional case series.

Methods: Human plasmin was injected into rabbit eyes.