Publications by authors named "Kunihiro Ito"
Article Synopsis
- Choanal atresia with an extra nostril on the columella is a rare condition in infants that can lead to serious breathing issues since they primarily breathe through their noses.
- A female infant was born with symptoms like retractive breathing and cyanosis, and imaging revealed she had bilateral membranous choanal atresia, requiring specialized oxygen support.
- The use of a mouthpiece helped improve her breathing without needing emergency surgery, demonstrating a successful management approach for this unique case.
Background: Epidermal growth factor receptor (EGFR) is frequently overexpressed in oral squamous cell carcinoma (OSCC), and EGFR-targeting therapeutics have been widely employed to treat patients with a variety of carcinomas including OSCC. Here, we aimed to investigate alternative signaling for OSCC survival under the disruption of EGFR signaling.
Methods: OSCC cell lines, namely HSC-3 and SAS, were utilized to investigate how EGFR disruption affects cell proliferation.
Article Synopsis
- PBK (PDZ-binding kinase) is identified as a poor prognostic factor for cancer, and the study investigates the effects of a specific PBK inhibitor, OTS514, on oral squamous cell carcinoma (OSCC) cells.
- The research utilized four OSCC cell lines to assess cell survival and apoptosis, with OTS514 reducing cell survival and promoting apoptosis in a dose-dependent manner.
- Findings suggest OTS514 inhibits OSCC cell growth by downregulating E2F target genes and inducing apoptosis through the p53 signaling pathway, indicating its potential as a targeted cancer therapy.
Objectives: People with cancer have a high risk of cachexia and sarcopenia, which are associated with worse clinical outcomes. We evaluated the prediction accuracy of the Matsuyama et al. and Ishida et al.
View Article and Find Full Text PDFObjectives: This study aimed to create a formula to estimate the third lumbar vertebra (L3) level skeletal muscle cross-sectional area (CSA), known as a standard value to evaluate skeletal muscle mass on computed tomography (CT), using the twelfth thoracic vertebra (Th12) level skeletal muscle CSA on chest CT.
Materials And Methods: This retrospective observational study included patients aged 40 + years with a diagnosis of oral squamous cell carcinoma (n = 164). Skeletal muscle CSA on CT images was measured using the Th12 and the L3 levels of pretreatment CT scans.
Article Synopsis
- Ameloblastoma is a rare but benign tumor of the head and neck, making up less than 1% of such tumors, with notable BRAF V600E and SMO L412F mutations identified through advanced sequencing techniques.
- Despite having genomic data, the full molecular signature and characteristics of ameloblastoma cells remain unclear, prompting further investigation in this study.
- Findings revealed a distinct gene expression pattern in ameloblastoma compared to normal tissues, with activation of KRAS-responsive genes, highlighting the role of IGF2 in cell proliferation and suggesting TLR2 signaling contributes to cell survival, which could lead to improved treatments.
NADPH oxidases, also known as the Nox family, are major sources of reactive oxygen species generation that regulate redox-sensitive signaling pathways. Recent studies have implicated the Nox family in cancer development and progression. However, the involvement of its members in the development of oral squamous cell carcinoma (OSCC) remains to be elucidated.
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