Publications by authors named "Kunihiro Hashimoto"
Article Synopsis
- The study evaluates the modified 5-item frailty index's effectiveness in predicting outcomes for patients undergoing radical nephroureterectomy for upper tract urothelial carcinoma.
- It categorizes patients into high and low frailty index groups, finding that those with higher scores experienced more severe complications and poorer survival rates.
- The results highlight the modified frailty index as a crucial tool for assessing surgical risk and predicting postoperative outcomes in these patients.
Treatment with a combination of norepinephrine and doxazosin was effective in a patient with pheochromocytoma who had blood pressure fluctuation, hypotension, and recurrent syncope. After adrenalectomy, his blood pressure, heart rate, and plasma levels of catecholamines remained normal and stable without any medication. ().
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- Adrenal incidentaloma (AI) is often found during clinical evaluations and can be linked to conditions like primary aldosteronism (PA) and subclinical Cushing's syndrome (SCS), which can sometimes occur together.
- A 58-year-old man experiencing abdominal pain and high blood pressure was found to have AI; further tests revealed he had both PA and SCS stemming from a cortisol-producing adenoma, confirmed after surgery.
- The case highlights the importance of thorough clinical evaluations to accurately diagnose patients with AI who may have coexisting endocrine disorders.
Background: Bone metastasis of prostate cancer is associated with pain and reduced overall survival (OS). Radium-223, which is expected to reduce bone pain and prolong OS, was recently approved in Japan.
Aim: The aim of this study was to investigate the usefulness of the bone scan index by comparing the outcomes and factors according to response in Japanese patients treated with radium-223.
Background: Lymphovascular invasion (LVI) in high-grade clinical T1 bladder cancer is usually considered a poor prognostic factor, but it is often difficult to achieve correct staging of T1 bladder cancer and diagnose the presence of LVI because of the inadequacy of conventional transurethral resection specimens. The aims of this study were to evaluate the prognostic value of LVI in patients with correctly staged high-grade pathological T1 (pT1) bladder cancer who initially underwent transurethral resection in one piece (TURBO).
Methods: Eighty-six high-grade pT1 bladder cancer patients who underwent TURBO were enrolled.
Objectives: To demonstrate the usefulness of transurethral resection in one piece (TURBO) as an accurate pathological staging tool for bladder tumor.
Methods: Ninety-seven patients with newly diagnosed bladder cancer underwent TURBO that was performed either in an en bloc or in a divisional manner. The histological quality of the resection specimens was evaluated and the pathological stage was assigned on the basis of the depth of invasion, which was histologically determined.
Purpose: We evaluated the role of tissue inhibitor of metalloproteinase-1 (TIMP-1) in the invasion and metastasis of human urothelial cancer.
Materials And Methods: The expression level of TIMP-1 messenger (m)RNA was determined in 33 urothelial carcinomas, including upper urothelial cancer in 15 cases and bladder cancer in 18, by Northern blot analysis. Localization of TIMP-1 mRNA was analyzed by in situ hybridization.