Publications by authors named "Kunichkina S"

The epidemiological HIV infection situation in the Ukraine in the past 4 years is analyzed. In patients with AIDS, the clinical manifestations of tuberculosis are atypical; prolonged intoxication, negative tuberculin tests, no bacterial isolation in half the cases. These patients should be treated with 4 - 5 antituberculous drugs, by taking into account the fact that only long-term continuous therapy may yield a positive effect.

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The authors investigated the clinical and biochemical efficacy of millimeter-wave resonance therapy in patients with destructive pulmonary tuberculosis associated with different concomitant diseases. It was established that inclusion of millimeter-wave resonance therapy in the complex treatment of this patient category favoured the efficacy of tuberculosis treatment. The treatment produced also a favourable effect on concomitant diseases.

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Computerized devices were used for evaluation of the state of pulmonary ventilation and central hemodynamics in 32 patients with pulmonary tuberculosis depending on the spread of the specific process. Patients with limited changes in the lungs, showed disorders of bronchial patency and compensatory increase of organic ejection of the right ventricle. In the presence of spread changes in the lungs the above mentioned changes were supplemented by restrictive ventilation disorders with a reduction of the contractile myocardial capacity.

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As a result of a study of 262 patients with chronic destructive tuberculosis of the lungs the authors revealed that these patients showed personality disorders that impede adequate treatment. Psychotherapy carried out in 5.2% of patients aimed at correction of personality disorders enabled to increase treatment efficacy of chronic destructive pulmonary tuberculosis.

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Lung ventilation and central hemodynamics in the course of treatment of 43 patients with pulmonary tuberculosis were studied. Registered ventilation and hemodynamic disturbances disappeared with an effectively conducted chemotherapy.

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The authors analyze 1080 cases of recurrence of tuberculosis of the respiratory organs with emphasis of their causes. It was found that recurrences were observed in subjects over 40 years of age that were dismissed from dispensary prophylactic examination or observed in subgroup VII-A and more frequently than freshly diagnosed tuberculosis showing bacteria discharge and pulmonary destruction. It was found that the leading cause of recurrence is an inadequate course of chemotherapy.

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The antiproteolytic activity of the blood serum was examined in the course of hospital treatment of 128 adolescents with prevailingly torpid forms of pulmonary tuberculosis and in 19 adolescents with tubercular infection (control). A direct correlation has been found between the degree of clinico-roentgenological manifestations of the disease and level of serum alpha 1-inhibitor of proteinases as well as between the efficacy of treatment and normalization of the antiproteolytic activity of the blood of the patients. It proposed to use the determination of alpha 1-inhibitor of proteinases as an additional criterion of evaluation of the clinical course and outcomes of the disease in adolescents.

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