[Polymorphism of gene p53 and apoptosis in patients with malignant lung disease--our observation].

Background: Many proved alterations in genoms of cells are said to be related to tumorigenesis. Apoptosis--a "programmed" death of cell, which has different morphology from necrosis, is one of the control mechanisms of cell division and participates in tumorigenesis.

Methods And Material: The authors present their results of analysis of the relation between genetic polymorphism of the p53 gene and the level of apopotosis in patients with confirmed malignant lung disease.

[Surgery in patients with organ transplants].

Patients after successful transplantation with immunosuppressive therapy form a "new circle of surgical patients" who can develop various surgical diseases, or injuries which bring about an inevitable urgent or planned surgical treatment. The authors present the results in three patients with transplanted organs (1993-1995) who were subdued to various surgical treatments. The first patient underwent a classical cholecystectomy, choledochotomy, and extraction of concrement from the choledochus after orthotopic transplantation of the heart.

[Aggressive angiomyxoma--a new clinico-pathologic entity].

The authors present a report on a new clinical and pathological entity--aggressive angiomyxoma which was described in 1983. They draw attention to the genesis of this tumour and its macro- and microscopic picture. They emphasize that treatment of this tumour involves its complete surgical extirpation and frequent local relapses without secondaries.

Panmyelic epidural cooling protects against ischemic spinal cord damage.

The neuroprotective effect of epidural cooling before and during spinal cord ischemia on the neurological, neurophysiological, and histopathological outcome was evaluated after 40 min of proximal and distal thoracic aorta crossclamping in dogs. In the normothermic group (n = 12), no attempt was made to change the spinal cord temperature. Four of eight animals showed complete paraplegia and four had partial recovery.

[Vascular care in devastating injuries of the extremities].

The authors present an account on the treatment of blood vessels in 15 patients with serious devastating injuries of the extremities in 1982-1989. In 10 patients the injury was on the upper and in 5 on the lower extremity. In the majority of patients for reconstruction of arteries and veins venous grafts were used.

Effect of axotomy on cholinergic enzyme activities in the spinal cord and sciatic nerve of the dog.

Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activity measured in the ventral and dorsal part of the dog spinal cord (L6-S2) and in the stumps of the sciatic nerve 5, 10, 15 and 21 days after its transection were compared with the corresponding activities in the intact contralateral nerve and in sham-operated animals. AChE was also examined histochemically. Changes in the enzyme activities in the central nerve stump were correlated with activity changes in the spinal cord.