Publications by authors named "Kundanika R Lakkadi"
PKCδ causes sepsis-induced cardiomyopathy by inducing mitochondrial dysfunction.
Am J Physiol Heart Circ Physiol
April 2020
Article Synopsis
- Sepsis-induced cardiomyopathy (SIC) leads to higher patient death rates, and currently, there are no targeted treatments available.
- Research shows that the protein PKCδ plays a crucial role in causing abnormal calcium handling and mitochondrial dysfunction in the heart during sepsis.
- Mice lacking PKCδ (knockout mice) exhibit better heart function and reduced mitochondrial damage compared to normal mice when exposed to sepsis, suggesting PKCδ could be a potential target for protection against cardiac issues in sepsis.
Dietary Saturated Fat Promotes Arrhythmia by Activating NOX2 (NADPH Oxidase 2).
Circ Arrhythm Electrophysiol
November 2019
Article Synopsis
- A high-saturated fat diet can increase the risk of arrhythmias and sudden cardiac death by affecting calcium homeostasis in the heart.
- The research in mice showed that saturated fat activates the enzyme NOX2, leading to dangerous changes in heart rhythm and calcium handling, while polyunsaturated fats do not have this effect.
- Inhibiting NOX2 can prevent the harmful heart effects of a high saturated fat diet, suggesting that NOX2 inhibitors might be a new treatment for heart rhythm issues related to excessive fat intake.