Innovative method for rapid detection of falsified COVID-19 vaccines through unopened vials using handheld Spatially Offset Raman Spectroscopy (SORS).

Preventing, detecting, and responding to substandard and falsified vaccines is of critical importance for ensuring the safety, efficacy, and public trust in vaccines. This is of heightened importance in context of public health crisis, such as the COVID-19 pandemic, in which extreme world-wide shortages of vaccines provided a fertile ground for exploitation by falsifiers. Here, a proof-of-concept study explored the feasibility of using a handheld Spatially Offset Raman Spectroscopy (SORS) device to authenticate COVID-19 vaccines through rapid analysis of unopened vaccine vials.

A novel high throughput plate-based method for 2-PE quantification in novel multidose vaccines (R21 malaria, Covishield and Covovax) and combination vaccines (Hexavalent).

Multidose presentation of vaccines is the most preferred choice, for mass immunization particularly during pandemics. WHO also recommends multidose containers of fill finished vaccines for programmatic suitability and global immunizations programmes. However, multidose vaccine presentations requires inclusion of preservatives to prevent contaminations.

Magnetically separable Zn Co Mg FeO ferrites: stable and efficient sunlight-driven photocatalyst for environmental remediation.

Nanomaterials have recently gained significant interest as they are believed to offer an outstanding prospect for use in environmental remediation. Among many possible candidates, due to their useful properties including magnetic nature, wide surface area, and high absorptivity, ferrite materials hold tremendous appeal, allowing them to be used for multifaceted applications. In the present study, using a sol-gel auto combustion process, a magnetically separable Zn Co Mg FeO ( = 0.

Left Ventricular Mid-Cavity Hypertrophic Cardiomyopathy with Myeloproliferative Neoplasm Leading to Multiple Cerebral Emboli.

Here we present a case of 55 year old male who presented with lower respiratory tract infection and clinical findings of systolic murmur at apex and hepatosplenomegaly and later on multiple cerebral emboli which on further evaluation turned out to be myeloproliferative neoplasm associated with cardiac mass with left ventricular mid-cavity obstruction.

Rare case report: mesocolonic dermoid cyst.

Mesenteric cysts are one of the most rare intra-abdominal tumours [1], classified as chylolymphatic, mesothelial (simple), enterogenous, urogenital remnant, dermoid cyst (teratomatous), gas, mycotic, parasitic, tubercular cysts and cysts following malignant degeneration [2]. Dermoid cysts are uncommon mesenteric cysts [3]. Cysts of the mesocolon are rare and usually differentiated from a mesenteric cyst only at the operation [4].

Rare case report - congenital diaphragmatic hernia presentation in adult.

Congenital diaphragmatic hernia (CDH) which mainly occurs in the newborn or in childhood with severe respiratory distress and high mortality, is rarely found in adults (Yamaguchi et al. Ann Thorac Cardiovasc Surg 8:106-108, 2002; Dalencourt and Katlic Ann Thorac Surg 82:721-722, 2006; Fraser et al. Endosc Percutan Tech 19: e5-e7, 2009; Kanazawa et al.

Intraluminal migration of surgical sponge: gossypiboma.

Surgical mop retained in the abdominal cavity following surgery is a serious but avoidable complication. The condition may manifest either as an exudative inflammatory reaction with formation of abscess, or aseptically with a fibrotic reaction developing into a mass. Intraluminal migration is relatively rare.

Hepatic trauma management and outcome; Our experience.

Background: Injuries to the liver have been reported in 35-45% of patients with significant blunt abdominal trauma. Since the introduction of ultrasonography and computerized tomography in the evaluation of these patients, there has been an increase in number of hepatic injuries diagnosed that previously would not have been apparent.

Aims And Objectives: The purpose of this study was to determine the epidemiology and pattern of isolated liver injury, significant factors related to management and outcome.

Formulation of intranasal mucoadhesive temperature-mediated in situ gel containing ropinirole and evaluation of brain targeting efficiency in rats.

Mucoadhesive temperature-mediated in situ gel formulations using chitosan and hydroxyl propyl methyl cellulose were used to enhance intranasal (i.n.) delivery of the dopamine D2 agonist ropinirole to the brain.

Brain targeting studies on buspirone hydrochloride after intranasal administration of mucoadhesive formulation in rats.

Objectives: The purpose of this study was to find out whether nasal application of buspirone could increase its bioavailability and directly transport the drug from nose to brain.

Methods: A nasal formulation (Bus-chitosan) was prepared by dissolving 15.5 mg buspirone hydrochloride, 1% w/v chitosan hydrochloride and 5% w/v hydroxypropyl beta-cyclodextrin (HP-beta-CD) in 5 ml of 0.