Publications by authors named "Kuncong Liu"
Mechanisms of HIF1A-mediated immune evasion in gastric cancer and the impact on therapy resistance.
Cell Biol Toxicol
October 2024
Article Synopsis
- Gastric cancer (GC) is a major health challenge with limited treatment effectiveness, leading researchers to investigate immune checkpoint inhibitors as a possible new approach despite resistance issues.
- This study explores the immunosuppressive mechanisms of quiescent cancer cells (QCCs) in GC, using various techniques to understand how they evade T-cell responses, particularly focusing on the role of HIF1A and glycolysis-related genes.
- Findings show that QCCs have a stronger resistance to T-cell attacks and alter the immune microenvironment, which downregulates T-cell activation; targeting HIF1A could enhance T-cell response and make QCCs more sensitive to immunotherapy.