Publications by authors named "KunQi Yang"

The gas sensitivity of the W defect in WS (V/WS) to five toxic gases-HCHO, CH, CHHO, CHOH, and CHCH-has been examined in this article. These five gases were adsorbed on the V/WS surface, and the band, density of state (DOS), charge density difference (CDD), work function (), current-voltage (I-V) characteristic, and sensitivity of adsorption systems were determined. Interestingly, for HCHO-V/WS, the energy level contribution of HCHO is closer to the Fermi level, the charge transfer () is the largest (0.

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The g-ZnO/SiC heterojunction is designed, and its stability, electronic properties and photo-electro catalytic properties, and the impact of biaxial strain on the electronic and photocatalytic properties are investigated. The g-ZnO/SiC heterojunction has a staggered (type-II) band structure (band gap is 1.770 eV), following the S-scheme mechanism.

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Liddle syndrome is an autosomal dominant form of monogenic hypertension that is caused by mutations in , or , which respectively encode the α, β and γ subunits of the epithelial sodium channel. In the present study, DNA was extracted from leukocytes in peripheral blood obtained from all members of a family with Liddle syndrome. Whole‑exome sequencing and Sanger sequencing were performed to assess the candidate variant and a co‑segregation analysis was conducted.

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Purpose: The presence of elevated fibrinogen levels is associated with cardiovascular disease. However, whether fibrinogen level is associated with adverse clinical events in patients with psoriasis and coronary artery disease (CAD) is unknown. This study aimed to investigate the relationship between fibrinogen levels and cardiovascular adverse events in these patients.

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Background: The prognostic value of lipoprotein (Lp) (a) in patients who have suffered from coronary artery disease (CAD) has not been fully studied, and the results are inconsistent. This study was conducted to evaluate whether increased Lp(a) concentrations cause differences in clinical adverse outcomes in patients with psoriasis who have already suffered from CAD.

Methods: This retrospective cohort study included consecutive patients with psoriasis and CAD between January 2017 and May 2022 in our hospital.

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Introduction: Neurofibromatosis type 1 (NF-1) is caused by mutations in the NF1 gene that encodes neurofibromin, a negative regulator of RAS proto-oncogene. Approximately one-third of the reported pathogenic mutations in NF1 are splicing mutations, but most consequences are unclear. The objective of this study was to identify the pathogenicity of splicing mutation in a Chinese family with NF-1 and determine the effects of the pre-mRNA splicing mutation by in vitro functional analysis.

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To evaluate the potential predictive value of total bilirubin (TBIL) for one-year prognosis in patients with coronary artery disease (CAD) and psoriasis. 278 psoriasis patients who underwent coronary angiography and were diagnosed as CAD were recruited. Baseline TBIL was measured at admission.

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Background: Psoriasis is associated with an increased prevalence of cardiovascular risk factors, including metabolic syndrome (MetS). To date, it is unclear whether MetS causes differences in cardiovascular outcomes in psoriatic patients with coronary artery disease.

Methods: We conducted a retrospective cohort study to determine the effects of MetS in psoriatic patients with coronary artery disease.

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Article Synopsis
  • Sengers syndrome is a rare genetic disorder characterized by hypertrophic cardiomyopathy, and this study reports the first known case associated with left ventricular non-compaction (LVNC).
  • Genetic testing revealed a novel compound heterozygous splicing mutation in the AGK gene, affecting the protein's structure and function, which was confirmed through both computational and laboratory methods.
  • The findings suggest that patients with AGK splicing mutations might exhibit milder forms of Sengers syndrome and could lead to improved understanding and potential treatment options for this condition.
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Spraying chemical pesticides is one of the important means to control plant pest, and the profile variable spraying is an important technology to achieve precise pesticide application. A profiling tracking control method and an improved algorithm based on CMAC-PID (Cerebellar Model Articulation Controller- Potential Induced Degradation) were proposed in the paper. The test results of the sprayer profiling tracking of the tree canopies showed that the profiling control system using the improved algorithm had significantly better dynamic tracking performance, and the overall mean tracking error was reduced by 35.

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Article Synopsis
  • Apparent mineralocorticoid excess (AME) is a genetic condition that leads to low-renin hypertension, low aldosterone levels, and high cortisol to cortisone metabolite ratios due to mutations in the HSD11B2 gene.* -
  • It affects the enzyme 11β-HSD2, which converts cortisol to cortisone, and has over 50 identified mutations that impair enzyme function through various molecular mechanisms.* -
  • Early and accurate diagnosis through genetic testing is crucial for effective management of AME, helping to prevent severe health complications related to target organ damage.*
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2D ZnO is one of the most attractive materials for potential applications in photocatalysis, gas and light detection, ultraviolet light-emitting diodes, resistive memory, and pressure-sensitive devices. The electronic structures, magnetic properties, and optical properties of M (Li, Na, Mg, Ca, or Ga) and TM (Cr, Co, Cu, Ag, or Au) adsorbed g-ZnO were investigated with density functional theory (DFT). It is found that the band structure, charge density difference, electron spin density, work function, and absorption spectrum of g-ZnO can be tuned by adsorbing M or TM atoms.

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Objective: Liddle syndrome (LS) is a monogenic hypertension consistent with autosomal dominant inheritance, often with early onset high blood pressure in childhood or adolescence. This study aimed to identify the pathogenicity of a nonsense mutation in in a Chinese family with LS and the long-term outcomes of tailored treatment with amiloride.

Methods: To explore the pathogenicity of candidate variant reported in 2015 by our team, we constructed mutant and wild-type models and measured amiloride-sensitive current in () cells using patch clamp technique.

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Familial PHEOs (pheochromocytomas) are inherited as an autosomal dominant trait, and inherited PHEOs can be one clinical phenotype of clinical syndromes, such as multiple endocrine neoplasia type 2A (MEN2A). In recent years, there has been a lot of controversy about the factors affecting the penetrance of PHEOs in MEN2A, of which the effects of RET (rearranged during transfection) proto-oncogene mutations are the primary concern. In this report, we performed genetic screening of patients in one family presenting with PHEOs and found they carried a RET c.

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Hypertension is an important risk factor in many conditions and creates a heavy burden of disease and mortality globally. Polygenic hypertension is the most common form; however, it is increasingly recognized that monogenic hypertension is not rare, especially in patients with electrolyte disorders. Single genetic alterations are associated with plasma volume expansion and catecholamines/sympathetic excess with simultaneously increased potassium excretion in the urine and potassium intracellular shift.

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Objective: To determine the prognostic role of big endothelin-1 (ET-1) in left ventricular non-compaction cardiomyopathy (LVNC).

Methods: We prospectively enrolled patients whose LVNC was diagnosed by cardiac MRI and who had big ET-1 data available. Primary end point was a composite of all-cause mortality, heart transplantation, sustained ventricular tachycardia/fibrillation and implanted cardioverter defibrillator discharge.

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Purpose: Apparent mineralocorticoid excess (AME) is an ultrarare autosomal recessive disorder resulting from deficiency of 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) caused by mutations in HSD11B2. The purpose of this study was to identify novel compound heterozygous HSD11B2 mutations in a Chinese pedigree with AME and conduct a systematic review evaluating the AME clinical features associated with HSD11B2 mutations.

Methods: Next-generation sequencing was performed in the proband, and Sanger sequencing was used to identify candidate variants in family members, 100 hypertensives, and 100 healthy controls.

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Background: Primary aldosteronism (PA) increases the risk of cardiovascular morbidity, including stroke, coronary artery disease, atrial fibrillation, and heart failure. The relationship between primary aldosteronism and aortic dissection has rarely been reported. We report a case of aortic dissection caused by secondary hypertension from PA and review similar cases in the literature.

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Article Synopsis
  • Liddle syndrome (LS) is a hereditary condition linked to hypertension, caused by mutations in the ENaC genes SCNN1A, SCNN1B, and SCNN1G.
  • This study identified a new missense mutation in the SCNN1B gene within a Chinese family that has a history of stroke and confirmed its link to LS through genetic testing.
  • The novel mutation led to significant changes in the protein structure, and treatments with amiloride were shown to effectively manage hypertension and improve potassium levels in affected family members.
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Rare cases of concurrent primary aldosteronism (PA) and renal artery stenosis (RAS) have been reported. In this retrospective case-control study, we selected a cohort of 10 PA with RAS patients and a control group of 20 PA without RAS patients from January 1, 2006, to January 1, 2016.  All patients presented with refractory hypertension, and a nonstatistically significant trend toward lower mean serum potassium was seen in the PA with RAS group (p =.

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Article Synopsis
  • Progressive cardiac conduction defect (PCCD) is an inherited genetic disorder that causes age-related issues with heart electrical signals, and researchers aimed to find the mutation causing it in a Chinese family with PCCD.
  • The study involved 39 family members, where whole-exome sequencing was conducted on four individuals, leading to the discovery of a specific mutation (c.1443C>A) in the LMNA gene associated with PCCD symptoms like bradycardia.
  • The findings suggest that genetic screening and family counseling are crucial for managing PCCD, with possible interventions like early pacemaker implantation to balance risk and treatment options.
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Background: Liddle syndrome (LS), an autosomal dominant disorder, is a common monogenic hypertension in pediatrics. In this study, we reported a novel SCNN1G variant in a Chinese family with pediatric LS, and conduct a systematic review of epithelial sodium channel (ENaC)-gene-positive LS cases to conclude the clinical genetic features of LS in childhood.

Methods: Next-generation sequencing and in silico analysis were performed in the proband to discover candidate variants.

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Background: Hypertension and brachydactyly syndrome (HTNB), also called Bilginturan syndrome, is a rare autosomal dominant disorder characterized by severe salt-independent hypertension, a short stature, brachydactyly, and death from stroke before the age of 50 years when untreated. The purpose of the present study was to identify a PDE3A mutation leading to HTNB associated with vertebral artery malformation in a Chinese family.

Methods: Peripheral blood samples were collected from all subjects for DNA extraction.

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