Publications by authors named "Kun-zi Yu"

Article Synopsis
  • Few studies have examined the heavy metal accumulation in traditional Chinese medicines (TCMs), specifically investigating lead, cadmium, arsenic, mercury, and copper in traditional animal medicines.
  • The research introduced a comprehensive health risk assessment approach that evaluates the bioaccessible levels of these heavy metals, calculating metrics like target hazard quotient (THQ), target hazard index (THI), and cancer risk (CR).
  • Findings indicated that mercury had the lowest bioaccessibility, and overall, traditional animal medicines appear to pose a minimal health risk to the general community, with cancer risk levels for arsenic and lead remaining below accepted clinical thresholds.
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The Chinese Materia Medica, Tiepishihu, used as a tonic for over one thousand years, is a well-known precious medicine in China. According to the Chinese Pharmacopoeia, its source is the species Dendrobium officinale Kimura et Migo, which is distinguished from other species in Dendrobium genus. However, these species from the same genus are similar with Tiepishihu and caused confusion in the market.

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An ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry method coupled with principal component analysis was developed and applied to the identification of Cornu Antelopis, Cornu Bubali, Cornu Naemorhedi, and Cornu Bovis. The data obtained from the trypsin-digested samples were subjected to principal component analysis to classify these four cornua. Additionally, marker peptides of the cornua were determined by orthogonal partial least-squares discriminant analysis, and fragmentation tandem mass spectra of these marker peptides were evaluated.

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The paper is aimed to establish a methods for identication of pearl powder and conch powder from different origins. Hermetic aluminum pan was used to encapsulate samples. The optimal testing conditions were: heating rate 10 degrees C x min(-1), sample weight 3 mg and nitrogen gas flow rate 40 mL x min(-1).

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Astragali Radix is a widely and commonly used Chinese herbal medicine, which is derived from roots of Astragalus membranaceus var. mongholicus and Astragalus membranaceus. To find a quick and reliable method of distinguishing these two species of Astragali Radix and of determining the age of a sample, microscopic characteristics of the two species were compared using light microscopy.

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