Publications by authors named "Kun-hua Chen"

Objective: To explore the causes of nonspecific chronic cough in children and relationship between transient receptor potential vanilloid 1 (TRPV1) gene polymorphisms and nonspecific chronic cough.

Methods: A total of 195 children with chronic cough were followed up half a month, one month and three months after their first visit to hospital. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to examine polymorphisms of the TRPV1 gene in the children.

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Objective: To investigate the proportion of incidence of children with non-specific chronic cough in Chongqing and analyze the characteristics of etiology during the follow-up.

Method: Diagnostic criteria were defined for children with non-specific chronic cough according to the Guidelines of diagnosis and therapy for children with chronic cough that were formulated by the Subspecialty Group, Society of Pediatrics, Chinese Medical Association and Chinese Journal of Pediatrics in 2008. Totally 266 patients in whom cough was the main or the only symptom,lasting > 4 weeks, presenting to Asthma Center of Children's Hospital, Chongqing Medical University between June 2008 and April 2009 were recruited into this study.

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Objective: Tracheobronchomalacia is one of the common respiratory tract dysplasia in children. Its symptoms are nonspecific, and routine methods are unreliable in the assessment of tracheobronchomalacia in children. In addition, many physicians are confused about its clinical characteristics, so tracheobronchomalacia is often underdiagnosed.

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Article Synopsis
  • The study aims to investigate how Foxp3 expression and regulatory T cells influence the development of asthma in children.
  • It involved 40 participants, including children experiencing asthma attacks, those in remission, and a control group with no allergic history, using various tests to analyze T cell percentages and cytokine levels.
  • Results showed that both asthmatic groups had lower levels of regulatory T cells and Foxp3-mRNA compared to controls, indicating a potential link between these factors and asthma severity.
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