Publications by authors named "Kun-Yi Cai"
Post-traumatic stress disorder (PTSD) is characterized by anxiety, excessive fear, distress, and weakness as symptoms of a psychiatric disorder. However, the mechanism associated with its symptoms such as anxiety-like behaviors is not well understood. It is aimed to investigate the underlying mechanisms of the medial septum (MS)-medial habenula (MHb) neural circuit modulating the anxiety-like behaviors of PTSD mice through in vivo fiber photometry recording, optogenetics, behavioral testing by open-field and elevated plus maze, fluorescent gold retrograde tracer technology, and viral tracer technology.
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- PTSD is linked to cardiovascular disease, and this study investigates a possible glutamatergic connection between the medial habenula (MHb) and the rostral ventrolateral medulla (RVLM) in rats.
- Researchers used techniques like retrograde labeling and microinjections to assess how stimulation of the MHb affects RVLM neuron activity, heart rate, and blood pressure in PTSD-affected rats.
- The results indicate that the connection between MHb and RVLM involves NMDA and AMPA receptors, suggesting this pathway plays a role in regulating cardiovascular functions in rats with PTSD.
Article Synopsis
- PTSD is linked to a higher risk of cardiovascular disease, and this study investigates the role of amygdala glutamate receptors in cardiovascular function using a rat PTSD model.
- The PTSD model was created using a combination of electrical stimulation and prolonged stress, with behavioral assessments showing significant differences in weight gain and anxiety-like behavior compared to a control group.
- Results indicated that AMPA receptors in the amygdala influence cardiovascular activity; blockers of these receptors increased heart rate and neuron firing, suggesting their potential role in cardiovascular issues related to PTSD.
In this study, a series of curcumin derivatives containing 1,2,3-triazole were designed and synthesized, and their inhibitory activities against the proliferation of lung cancer cells were studied. Compound 5 k (3,4-dichlorobenzyltriazole methyl curcumin) had the best activity against A549 cells, with a half-maximal inhibitory concentration (IC ) of 2.27 μM, which was approximately 10 times higher than that of the lead curcumin and higher than that of gefitinib (IC =8.
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